Tavaborole
SIGMA/SML1227 - ≥95% (HPLC)
Synonym: 1,3-
CAS Number: 174671-46-6
Empirical Formula (Hill Notation): C7H6BFO2
Molecular Weight: 151.93
Linear Formula: C7H6BFO2
Product Type: Chemical
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| assay | ≥95% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C7H6BFO2/c9-6-1-2-7-5( |
| InChI key | LFQDNHWZDQTITF-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | B1(OCc2c1ccc(c2)F)O |
| solubility | DMSO: 20 mg/mL, clear |
| storage condition | desiccated |
| storage temp. | −20°C |
| Biochem/physiol Actions: | Tavaborole (AN2690) is a potent antifungal that targets the post-transfer editing site of leucyl-tRNA synthetase (LeuRS). |
| Biochem/physiol Actions: | Tavaborole (AN2690) is a potent antifungal that targets the post-transfer editing site of leucyl-tRNA synthetase (LeuRS). Tavaborole forms a covalent adduct with the 3′ adenosine of tRNA(leu) at the editing site of fungal, but not bacterial LeuRS, locking the enzyme in an inactive conformation. Tavaborole was recently approved for the treatment of onychomycosis of the toenail in adults. |
| General description: | Tavaborole is a boron-based pharmaceutical agent. It has broad-spectrum oxaborole antifungal activity. Due to its low molecular weight, it facilitates maximal nail plate penetration than its predecessors. |
| Packaging: | 10, 50 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |