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cGAMP sodium salt

SIGMA/SML1232 - ≥98% (HPLC)

Synonym: 3′3′-cGAMP sodium salt; Cyclic AMP-GMP sodium salt; c-GMP-AMP sodium salt; cyclic GMP-AMP sodium salt

CAS Number: 849214-04-6 (free acid)
Empirical Formula (Hill Notation): C20H24N10O13P2 · xNa+
Molecular Weight: 674.41 (free acid basis)
Linear Formula: C20H24N10O13P2 · xNa+
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1232-.5UMO 0.5 µmol
 $233.00
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assay ≥98% (HPLC)
color white to beige
description contains 0.5μmol of powder (approx. 0.335mg)
form powder
Quality Level 100 
SMILES string O=C1N=C(N)NC2=C1N=CN2[C@H](O3)[C@H](O)[C@H](OP4(O)=O)[C@H]3COP(O)(O[C@H]5[C@@H](O)[C@H](N6C=NC7=C6N=CN=C7N)O[C@@H]5CO4)=O.C
storage temp. −20°C
Application: cGAMP sodium salt has been used in cGAS-cGAMP Activity Assay.
Biochem/physiol Actions: cGAMP induces the formation of cytokines (interferon-β, interferon-γ), activation of dendritic cells and CD8+ T cell cross priming. Through this action, it promotes innate immune response. cGAMP possesses antitumor activity and is prefered for immunotherapy in cancer treatment.
Biochem/physiol Actions: Cyclic AMP-GMP (cGAMP) is a bacterial second messenger.
Biochem/physiol Actions: Cyclic AMP-GMP (cGAMP) is one of several naturally occurring cyclic dinucleotides that act as a bacterial second messengers to regulate important signaling mechanisms in prokaryotes that control bacterial survival, adhesion, colonization, biofilm formation, and virulence factors production. In cholera c-AMP-GMP promotes intestinal colonization by down-regulating chemotaxis. During infections bacterial cGAMP is bound by host STING (stimulator of interferon genes) activating innate immune responses leading to expression of interferon genes.
Preparation Note: Cyclic AMP-GMP is soluble in water and aqueous buffers (> 10 mM, limits have not been determined).
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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