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CCT137690

SIGMA/SML1237 - ≥98% (HPLC)

Synonym: 6-Bromo-7-[4-[(5-methyl-3-isoxazolyl)methyl]-1-piperazinyl]-2-[4-(4-methyl-1-piperazinyl)phenyl]-3H-imidazo[4,5-b]pyridine

CAS Number: 1095382-05-0
Empirical Formula (Hill Notation): C26H31BrN8O
Molecular Weight: 551.48
MDL Number: MFCD18206879
Linear Formula: C26H31BrN8O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1237-5MG 5 mg
 $128.00
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assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C26H31BrN8O/c1-18-15-20(31-36-18)17-33-9-13-35(14-10-33)24-22(27)16-28-26-23(24)29-25(30-26)19-3-5-21(6-4-19)34-11-7-32(2)8-12-34/h3-6,15-16H,7-14,17H2,1-2H3,(H,28,29,30)
InChI key GFLQCBTXTRCREJ-UHFFFAOYSA-N
Quality Level 100 
SMILES string CN(CC1)CCN1C(C=C2)=CC=C2C3=NC4=C(N5CCN(CC6=NOC(C)=C6)CC5)C(Br)=CN=C4N3
solubility DMSO: 2 mg/mL, clear (warmed)
storage temp. −20°C
Biochem/physiol Actions: CCT137690 is a very potent, orally bioavailble, pan aurora kinase inhbitor (IC50 = 15, 25, and 19 nM for Aurora A, B and C respectively). CCT137690 inhibits tumor growth in amouse xenograft model and causes multipolar spindle formation, chromosome misalignment, polyploidy and apoptosis in tumor cell lines.
Biochem/physiol Actions: CCT137690 is a very potent, orally bioavailble, pan aurora kinase inhbitor.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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