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Pyr6

SIGMA/SML1241 - ≥98% (HPLC)

Synonym: N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoro-4-pyridinecarboxamide

CAS Number: 245747-08-4
Empirical Formula (Hill Notation): C17H9F7N4O
Molecular Weight: 418.27
Linear Formula: C17H9F7N4O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1241-5MG 5 mg
 $103.00
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45-SML1241-25MG 25 mg
 $323.00
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assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C17H9F7N4O/c18-12-8-25-6-5-11(12)15(29)26-9-1-3-10(4-2-9)28-14(17(22,23)24)7-13(27-28)16(19,20)21/h1-8H,(H,26,29)
InChI key XZIQSOZOLJJMFN-UHFFFAOYSA-N
Quality Level 100 
SMILES string O=C(C1=CC=NC=C1F)NC2=CC=C(N3C(C(F)(F)F)=CC(C(F)(F)F)=N3)C=C2
solubility DMSO: 20 mg/mL, clear
storage temp. 2-8°C
Biochem/physiol Actions: Pyr6 is a selective inhibitor of calcium release from the endoplasmic reticulum via STIM1/Orai1 mediated, store operated calcium entry (SOCE).
Biochem/physiol Actions: Pyr6 is a selective inhibitor of calcium release from the endoplasmic reticulum via STIM1/Orai1 mediated, store operated calcium entry (SOCE). Pyr6 blocks SOCE in thapsigargin treated, calcium depleted BRL-2H3 cells (IC50 = 0.49 μM), but has poor activity against carbachol-induced, TRPC3-mediated calcium entry in TRPC3-transfected HEK293 cells (IC50 = 18.46 μM).
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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