SGC707

SIGMA/SML1242 - ≥98% (HPLC)

Synonym: 1-Isoquinolin-6-yl-3-(2-oxo-2-pyrrolidin-1-yl-ethyl)-urea

CAS Number: 1687736-54-4
Empirical Formula (Hill Notation): C₁₆H₁₈N₄O₂
Molecular Weight: 298.34
Linear Formula: C₁₆H₁₈N₄O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SML1242-5MG	5 mg	$104.00 1/EA		Add To Favorites
45-SML1242-25MG	25 mg	$286.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to light brown
form	powder
InChI	1S/C16H18N4O2/c21-15(20-7-1-2-8-20)11-18-16(22)19-14-4-3-13-10-17-6-5-12(13)9-14/h3-6,9-10H,1-2,7-8,11H2,(H2,18,19,22)
InChI key	DMIDPTCQPIJYFE-UHFFFAOYSA-N
Quality Level	100
SMILES string	O=C(NCC(N1CCCC1)=O)NC2=CC3=CC=NC=C3C=C2
solubility	DMSO: 20 mg/mL, clear
storage temp.	2-8°C

Biochem/physiol Actions:	SGC707 is a potent allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3).
Biochem/physiol Actions:	SGC707 is a potent allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3). SGC707 has an IC₅₀ value of 50 nM and >100-fold selectivity over other methyltransferases and non-epigenetic targets. SGC707 binds to PRMT3 with KD of 50 nM (ITC), and inhibits histone methylation in cells with an IC₅₀value below 1 μM. For full characterization details, please visit the SGC707 probe summary on the Structural Genomics Consortium (SGC) website. XY1 is the negative control for the active probe, SGC707. To request a sample of the negative control from the SGC, click here . To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
Features and Benefits:	SGC707 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC .
Features and Benefits:	This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Other Notes:	SGC707 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the SGC707 probe summary on the Chemical Probes Portal website.
Packaging:	5, 25 mg in glass bottle

Symbol	GHS05
Signal word	Danger
Hazard statements	H318
Precautionary statements	P280 - P305 + P351 + P338 + P310
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	51111800

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