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Pyr10

SIGMA/SML1243 - ≥98% (HPLC)

Synonym: N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methyl-benzenesulfonamide

CAS Number: 1315323-00-2
Empirical Formula (Hill Notation): C18H13F6N3O2S
Molecular Weight: 449.37
Linear Formula: C18H13F6N3O2S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1243-5MG 5 mg
 $129.00
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45-SML1243-25MG 25 mg
 $347.00
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This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI key CVALMMCIOLXHDM-UHFFFAOYSA-N
Quality Level 100 
SMILES string FC(F)(F)c1[n](nc(c1)C(F)(F)F)c2ccc(cc2)N[S](=O)(=O)c3ccc(cc3)C
solubility DMSO: 20 mg/mL, clear
storage temp. 2-8°C
Biochem/physiol Actions: Pyr10 is a novel, selective inhibitor of the transient receptor potential channel TRPC3.
Biochem/physiol Actions: Pyr10 is a novel, selective inhibitor of the transient receptor potential channel TRPC3. Pyr10 blocks carbachol-induced calcium entry into TRPC3-transfected HEK293 cells (IC50 = 0.72 μM), with significantly lower activity against STIM1/Orai1 mediated release of calcium from endoplasmic reticulum (store operated calcium entry) in BRL-2H3 cells (IC50 = 13.08 μM).
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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