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JNK-IN-8

SIGMA/SML1246 - ≥96% (HPLC)

Synonym: 3-[[4-(Dimethylamino)-1-oxo-2-buten-1-yl]amino]-N-[3-methyl-4-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-benzamide

CAS Number: 1410880-22-6
Empirical Formula (Hill Notation): C29H29N7O2
Molecular Weight: 507.59
MDL Number: MFCD22124890
Linear Formula: C29H29N7O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1246-5MG 5 mg
 $195.00
1/EA		 Add To Favorites
45-SML1246-25MG 25 mg
 $742.00
1/EA		 Add To Favorites

 

assay ≥96% (HPLC)
color white to beige
form powder
InChI 1S/C29H29N7O2/c1-20-17-24(11-12-25(20)34-29-31-15-13-26(35-29)22-8-5-14-30-19-22)33-28(38)21-7-4-9-23(18-21)32-27(37)10-6-16-36(2)3/h4-15,17-19H,16H2,1-3H3,(H,32,37)(H,33,38)(H,31,34,35)
InChI key GJFCSAPFHAXMSF-UHFFFAOYSA-N
Quality Level 100 
SMILES string O=C(C1=CC(NC(C=CCN(C)C)=O)=CC=C1)NC(C=C2C)=CC=C2NC3=NC=CC(C4=CC=CN=C4)=N3
solubility DMSO: 20 mg/mL, clear
storage temp. 2-8°C
Application: JNK-IN-8 has been used as an inhibitor to address the importance of JNK signaling in withaferin A (WFA)-induced apoptosis of myelodysplastic syndromes (MDS)-L cells.
Biochem/physiol Actions: JNK-IN-8 and lapatinib synergistically reduce cell viability in human triple negative breast cancers (TNBC) cell lines by inducing apoptosis. JNK-IN-8 and lapatinib result in accumulation of cytotoxic oxidative stress.
Biochem/physiol Actions: JNK-IN-8 is a potent, selective and irreversible inhibitor of JNK1/2/3 that inhibits phosphorylation of c-Jun. JNK-IN-8 forms covalent bonds with a conserved cysteine residue.
Biochem/physiol Actions: JNK-IN-8 is a potent, selective and irreversible inhibitor of JNK1/2/3.
Other Notes: JNK-IN-8 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the JNK-IN-8 probe summary  on the Chemical Probes Portal website.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥96% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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