Gomisin A
SIGMA/SML1251
Synonym: (+)-Gomisin A; (6S,7S,13aR)- 5,6,7,8-
CAS Number: 58546-54-6
Empirical Formula (Hill Notation): C23H28O7
Molecular Weight: 416.46
Linear Formula: C23H28O7
Product Type: Chemical
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This image depicts SML1251-25MG.
This image depicts SML1251-25MG.
| biological source | Schisandra chinensis |
| color | white to beige |
| form | powder |
| InChI | 1S/C23H28O7/c1-12-7-13-8- |
| InChI key | ZWRRJEICIPUPHZ-MYODQAERSA |
| Quality Level | 100  |
| SMILES string | C[C@]1([H])[C@@](C)(O)CC2 |
| solubility | DMSO: 20 mg/mL, clear |
| storage temp. | −20°C |
| Biochem/physiol Actions: | Gomisin A guards against hepatic and renal injury stimulated by CCl(4) (carbon tetrachloride) exposure by differential modulation of the mitogen-activated protein kinases (MAPK) signal transduction pathway. It also blocks inflammatory responses, promoted by lipopolysaccharide in N9 microglia by blocking the NF-κB (nuclear factor kappa light chain enhancer of activated B cells)/MAPKs pathway. |
| Biochem/physiol Actions: | Gomisin A is a major dibenzocyclooctadiene lignan from medicinal plant Schizandra Chinese that exhibit a wide variety of interesting biological activities, including hepatoprotective, antiviral, anticancer, neuroprotective and anti-inflammatory. Gomisin A suppressed the expressions of iNOS and COX-2 in LPS-stimulated N9 microglia through suppression of NF-κB/MAPKs pathway. |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |