Synonym: (+)-Gomisin A; (6S,7S,13aR)- 5,6,7,8-Tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethyl-benzo[3,4]cycloocta[1,2-f][1,3]benzodioxol-6-ol; Besigomsin; Schisandrol B; Schisantherinol B; Schizandrol B; TJN 101; Wuweizi alcohol B; Wuweizichun B
CAS Number: 58546-54-6
Empirical Formula (Hill Notation): C23H28O7
Molecular Weight: 416.46
Linear Formula: C23H28O7
Product Type: Chemical
| biological source |
Schisandra chinensis |
| color |
white to beige |
| form |
powder |
| InChI |
1S/C23H28O7/c1-12-7-13-8-16-20(30-11-29-16)22(28-6)17(13)18-14(10-23(12,2)24)9-15(25-3)19(26-4)21(18)27-5/h8-9,12,24H,7,10-11H2,1-6H3/t12-,23-/m0/s1 |
| InChI key |
ZWRRJEICIPUPHZ-MYODQAERSA-N |
| Quality Level |
100  |
| SMILES string |
C[C@]1([H])[C@@](C)(O)CC2=C(C(OC)=C(OC)C(OC)=C2)C3=C(OC)C4=C(OCO4)C=C3C1 |
| solubility |
DMSO: 20 mg/mL, clear |
| storage temp. |
−20°C |
| Biochem/physiol Actions: |
Gomisin A guards against hepatic and renal injury stimulated by CCl(4) (carbon tetrachloride) exposure by differential modulation of the mitogen-activated protein kinases (MAPK) signal transduction pathway. It also blocks inflammatory responses, promoted by lipopolysaccharide in N9 microglia by blocking the NF-κB (nuclear factor kappa light chain enhancer of activated B cells)/MAPKs pathway. |
| Biochem/physiol Actions: |
Gomisin A is a major dibenzocyclooctadiene lignan from medicinal plant Schizandra Chinese that exhibit a wide variety of interesting biological activities, including hepatoprotective, antiviral, anticancer, neuroprotective and anti-inflammatory. Gomisin A suppressed the expressions of iNOS and COX-2 in LPS-stimulated N9 microglia through suppression of NF-κB/MAPKs pathway. |
| Packaging: |
5, 25 mg in glass bottle |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Storage Temp. |
−20°C |
| UNSPSC |
12352200 |
