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CASIN

SIGMA/SML1253 - ≥98% (HPLC)

Synonym: 2-[(2,3,4,9-Tetrahydro-6-phenyl-1H-carbazol-1-yl)amino]ethanol; Cdc42 Activity-Specific Inhibitor

CAS Number: 425399-05-9
Empirical Formula (Hill Notation): C20H22N2O
Molecular Weight: 306.40
MDL Number: MFCD01853271
Linear Formula: C20H22N2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1253-5MG 5 mg
 $129.00
1/EA		 Add To Favorites
45-SML1253-25MG 25 mg
 $509.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color , white to very dark brown
form powder
InChI 1S/C20H22N2O/c23-12-11-21-19-8-4-7-16-17-13-15(14-5-2-1-3-6-14)9-10-18(17)22-20(16)19/h1-3,5-6,9-10,13,19,21-23H,4,7-8,11-12H2
InChI key RXIUMAOXORBRCY-UHFFFAOYSA-N
Quality Level 100 
SMILES string OCCNC1CCCC2=C1NC3=C2C=C(C4=CC=CC=C4)C=C3
solubility DMSO: 20 mg/mL, clear
storage temp. 2-8°C
Application: CASIN has been used as a cell division control protein 42 homolog (Cdc42) inhibitor:
• to study its effects on the stimulation of extracellular vesicles (EVs) in intestinal epithelial cells
• to study its effects on mice jejunum
• to study its effects on microbial adhesion-triggered endocytosis (MATE) vesicle morphology in segmented filamentous bacteria (SFB)-colonized mice
Biochem/physiol Actions: CASIN is an inhibitor of Cdc42 GTPase, a small GTPase of the Rho-subfamily that plays important roles in cytoskeleton organization, cell cycle progression, signal transduction, and vesicle trafficking. CASIN generated a rejuvenated phenotype of Hematopoietic stem cells (HSCs), reversing the aging-related and polarity phenotype of aged HSCs to that of young HSCs in vivo..
Biochem/physiol Actions: CASIN is an inhibitor of Cdc42 GTPase.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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