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GSK2194069

SIGMA/SML1259 - ≥97% (HPLC)

Synonym: (S)-4-(4-(Benzofuran-5-yl)phenyl)-3-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)methyl)-1H-1,2,4-triazol-5(4H)-one

CAS Number: 1332331-08-4
Empirical Formula (Hill Notation): C25H24N4O3
Molecular Weight: 428.48
MDL Number: MFCD28167807
Linear Formula: C25H24N4O3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1259-5MG 5 mg
 $207.00
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45-SML1259-25MG 25 mg
 $830.00
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assay ≥97% (HPLC)
color white to light brown
form powder
InChI 1S/C25H24N4O3/c30-24(18-1-2-18)28-11-9-16(15-28)13-23-26-27-25(31)29(23)21-6-3-17(4-7-21)19-5-8-22-20(14-19)10-12-32-22/h3-8,10,12,14,16,18H,1-2,9,11,13,15H2,(H,27,31)/t16-/m0/s1
InChI key AQTPWCUIYUOEMG-INIZCTEOSA-N
Quality Level 100 
SMILES string O=C(C1CC1)N2CC[C@@H](CC(N3C4=CC=C(C5=CC=C(OC=C6)C6=C5)C=C4)=NNC3=O)C2
solubility DMSO: 5 mg/mL, clear (warmed)
storage temp. 2-8°C
Biochem/physiol Actions: GSK2194069 is a fatty acid synthase (FAS) inhibitor.
Biochem/physiol Actions: GSK2194069 is a fatty acid synthase (FAS) inhibitor. GSK2194069 is a potent and specific inhibitor of the β-ketoacyl reductase (KR) activity of hFAS with an IC50 of 7.7 ± 4.1 nM for the overall hFAS reaction. FAS is upregulated in some cancers, including prostate cancer. GSK2194069 was found to inhibit tumour growth in prostate cancer C42b cell xenografts generated in Nod-SCID-gamma mice. Cellular FAS inhibition reduced cell growth were also demonstrated in non-small-cell lung (A549) cancer cell lines with an average EC50 of 15 ± 0.5 nM.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥97% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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