BQU57
SIGMA/SML1268 - ≥98% (HPLC)
Synonym: 6-
CAS Number: 1637739-82-2
Empirical Formula (Hill Notation): C16H13F3N4O
Molecular Weight: 334.30
Linear Formula: C16H13F3N4O
Product Type: Chemical
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This image depicts SML1268-25MG.
This image depicts SML1268-25MG.
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C16H13F3N4O/c1-8-12-13 |
| InChI key | IJCMHHSFXFMZAI-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | FC(F)(F)c1ccc(cc1)C2c3c([ |
| solubility | DMSO: 25 mg/mL, clear |
| storage temp. | 2-8°C |
| Biochem/physiol Actions: | BQU57 is a selective inhibitor of the Ras-like GTPases RalA and RalB, downstream mediators of Ras signalling, without direct inihibition of Ras or RhoA activity . BQU57 binds to a site on the GDP-bound form of Ral, its inactive state, inhibiting the binding of Ral to its effectors, such as Ral-binding protein 1 (RALBP1; also known as RLIP760, which are involved in proliferation, survival, and metastasis of several human cancers. BQU57 inhibited growth in human luung cancer cell lines with IC50 values of 2.0 μM in H2122 cells and 1.3 μM in H358 cells, and also inihbited tumor xenograft growth. |
| Biochem/physiol Actions: | BQU57 is a selective inhibitor of the Ras-like GTPases RalA and RalB. |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |