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BQU57

SIGMA/SML1268 - ≥98% (HPLC)

Synonym: 6-Amino-1,3-dimethyl-4-(4-(trifluoromethyl)phenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile; 6-Amino-1,4-dihydro-1,3-dimethyl-4-[4-(trifluoromethyl)phenyl]-pyrano[2,3-c]pyrazole-5-carbonitrile

CAS Number: 1637739-82-2
Empirical Formula (Hill Notation): C16H13F3N4O
Molecular Weight: 334.30
Linear Formula: C16H13F3N4O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1268-5MG 5 mg
 $103.00
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45-SML1268-25MG 25 mg
 $404.00
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This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C16H13F3N4O/c1-8-12-13(9-3-5-10(6-4-9)16(17,18)19)11(7-20)14(21)24-15(12)23(2)22-8/h3-6,13H,21H2,1-2H3
InChI key IJCMHHSFXFMZAI-UHFFFAOYSA-N
Quality Level 100 
SMILES string FC(F)(F)c1ccc(cc1)C2c3c([n](nc3C)C)OC(=C2C#N)N
solubility DMSO: 25 mg/mL, clear
storage temp. 2-8°C
Biochem/physiol Actions: BQU57 is a selective inhibitor of the Ras-like GTPases RalA and RalB, downstream mediators of Ras signalling, without direct inihibition of Ras or RhoA activity . BQU57 binds to a site on the GDP-bound form of Ral, its inactive state, inhibiting the binding of Ral to its effectors, such as Ral-binding protein 1 (RALBP1; also known as RLIP760, which are involved in proliferation, survival, and metastasis of several human cancers. BQU57 inhibited growth in human luung cancer cell lines with IC50 values of 2.0 μM in H2122 cells and 1.3 μM in H358 cells, and also inihbited tumor xenograft growth.
Biochem/physiol Actions: BQU57 is a selective inhibitor of the Ras-like GTPases RalA and RalB.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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