YZ9

SIGMA/SML1270 - ≥98% (HPLC)

Synonym: 3-Carbethoxy-7-hydroxycoumarin; 7-hydroxy-2-oxo-2H-1-benzopyran-3-carboxylic acid ethyl ester

CAS Number: 6093-71-6
Empirical Formula (Hill Notation): C₁₂H₁₀O₅
Molecular Weight: 234.20
Linear Formula: C₁₂H₁₀O₅
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SML1270-10MG	10 mg	$104.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C12H10O5/c1-2-16-11(14)9-5-7-3-4-8(13)6-10(7)17-12(9)15/h3-6,13H,2H2,1H3
InChI key	IETDBZQIWIJQJG-UHFFFAOYSA-N
Quality Level	100
SMILES string	[o]1c2c(cc([c]1=O)C(=O)OCC)ccc(c2)O
solubility	DMSO: 5 mg/mL, clear (warmed)
storage temp.	−20°C

Biochem/physiol Actions:	PFKFB3 inhibitor
Biochem/physiol Actions:	YZ9 is a 5, 6, 7, 8-tetrahydroxy-2-(4-hydroxyphenyl) chromen-4-one (N4A) inhibitor.
Biochem/physiol Actions:	YZ9 is a potent inhibitor of PFKFB3 (6-phosphfructo-2-kinase/fructose-2,6-bisphosphatase) with an IC₅₀ = 183 nM. PFKFB3 is over expressed in many cancers and catalyzes the production of fructose-2,6-bisphosphate, which can potentiate PFK1 activity, enhancing glycolysis in tumor cells. YZ9 dose dependently inhibits proliferation of HeLa cells.
Packaging:	10, 50 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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