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TWS119

SIGMA/SML1271 - ≥98% (HPLC)

Synonym: 3-[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy]phenol

CAS Number: 601514-19-6
Empirical Formula (Hill Notation): C18H14N4O2
Molecular Weight: 318.33
MDL Number: MFCD09037535
Linear Formula: C18H14N4O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1271-5MG 5 mg
 $121.00
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45-SML1271-25MG 25 mg
 $475.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C18H14N4O2/c19-12-4-1-3-11(7-12)16-9-15-17(22-16)20-10-21-18(15)24-14-6-2-5-13(23)8-14/h1-10,23H,19H2,(H,20,21,22)
InChI key VPVLEBIVXZSOMQ-UHFFFAOYSA-N
Quality Level 100 
SMILES string OC1=CC(OC2=NC=NC3=C2C=C(C4=CC=CC(N)=C4)N3)=CC=C1
solubility DMSO: 20 mg/mL, clear
storage temp. 2-8°C
Application: TWS119 has been used as glycogen synthase kinase-3β (GSK-3β) GSK3β inhibitor.
Biochem/physiol Actions: TWS119 favors the γδT cells survival and proliferation by activating the mammalian target of rapamycin (mTOR) pathway. It also promotes the expression of T-cell factor 1 (TCF1) and modulates cytokine production.
Biochem/physiol Actions: TWS119 is a potent Glycogen synthase kinase-3β (GSK-3β) inhibitor that can induce neurogenesis in embryonic stem cells (ESCs).
Biochem/physiol Actions: TWS119 is a potent Glycogen synthase kinase-3β (GSK-3β) inhibitor.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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