Geldanamycin-FITC
SIGMA/SML1277 - ≥98% (HPLC), from Streptomyces hygroscopicus
Synonym: Geldanamycin, fluorescein isothiocyanate labeled
Empirical Formula (Hill Notation): C55H63N5O13S
Molecular Weight: 1034.18
Linear Formula: C55H63N5O13S
Product Type: Chemical
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| antibiotic activity spectrum | neoplastics |
| assay | ≥98% (HPLC) |
| biological source | Streptomyces hygroscopicus |
| color | yellow to yellow-orange |
| form | powder |
| mode of action | enzyme | inhibits |
| Quality Level | 200  |
| solubility | DMSO: soluble 5 mg/mL |
| storage condition | protect from light |
| storage temp. | −20°C |
| Biochem/physiol Actions: | Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines. |
| Biochem/physiol Actions: | Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines. Geldanamycin binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, Geldanamycin is a potent inhibitor of the nuclear hormone receptor family. |
| Biochem/physiol Actions: | Geldanamycin-FITC is a fluorescent derivative of geldanamycin. It is used as a fluorescent tracer for heat shock protein 90 (HSP90) inhibitors in fluorescence polarization (FP) competition binding assay. |
| General description: | Chemical structure: benzenoid |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |