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Geldanamycin Ready Made Solution

SIGMA/SML1278 - 1 mg/mL, from Streptomyces hygroscopicus

Synonym: 2-Azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9,13-dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-, 9-carbamate (8CI)

CAS Number: 30562-34-6
Empirical Formula (Hill Notation): C29H40N2O9
Molecular Weight: 560.64
Linear Formula: C29H40N2O9
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1278-1ML 1 mL
 $253.00
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antibiotic activity spectrum neoplastics
biological source Streptomyces hygroscopicus
concentration 1 mg/mL
form DMSO solution
InChI 1S/C29H40N2O9/c1-15-11-19-25(34)20(14-21(32)27(19)39-7)31-28(35)16(2)9-8-10-22(37-5)26(40-29(30)36)18(4)13-17(3)24(33)23(12-15)38-6/h8-10,13-15,17,22-24,26,33H,11-12H2,1-7H3,(H2,30,36)(H,31,35)/b10-8-,16-9+,18-13+/t15-,17+,22+,23+,24-,26+/m1/s1
InChI key QTQAWLPCGQOSGP-KSRBKZBZSA-N
mode of action enzyme | inhibits
Quality Level 200 
shipped in dry ice
SMILES string N1C2=CC(=O)C(=C(C[C@H](C[C@@H]([C@@H]([C@H](C=C([C@@H]([C@H](C=C/C=C(/C1=O)C)OC)OC(=O)N)/C)C)O)OC)C)C2=O)OC
storage condition protect from light
storage temp. −20°C
Application: Geldanamycin Ready-Made Solution has been used as a heat shock protein 90 (Hsp90) inhibitor to pre-treat proteosome holo-enzyme during proteasome assay to study the role of proteasome on fibril fragmentation.
Biochem/physiol Actions: Geldanamycin is a benzoquinone ansamycin and is a well known tyrosine kinase inhibitor. It possesses anticancer effects and shows therapeutic effects against osteosarcoma.
Biochem/physiol Actions: Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines.
Biochem/physiol Actions: Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines. Geldanamycin binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, Geldanamycin is a potent inhibitor of the nuclear hormone receptor family.
General description: Chemical structure: benzenoid
WGK Germany WGK 1
Flash Point(F) 188.6 °F
Flash Point(C) 87 °C
Storage Temp. −20°C
UNSPSC 12352200

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