Tunicamycin Ready Made Solution

SIGMA/SML1287 - 5 mg/mL in DMSO, from Streptomyces sp.

CAS Number: 11089-65-9
Empirical Formula (Hill Notation): C₃₇H₆₀N₄O₁₆
Molecular Weight: 816.89
EC Number: 200-664-3
Linear Formula: C₃₇H₆₀N₄O₁₆
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SML1287-1ML	1 mL	$228.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

biological source	Streptomyces sp.
concentration	5 mg/mL in DMSO
form	DMSO solution
InChI	1S/C30H46N4O16/c1-11(2)5-4-6-16(38)32-19-23(43)20(40)14(47-29(19)50-28-18(31-12(3)36)22(42)21(41)15(10-35)48-28)9-13(37)26-24(44)25(45)27(49-26)34-8-7-17(39)33-30(34)46/h4,6-8,11,13-15,18-29,35,37,40-45H,5,9-10H2,1-3H3,(H,31,36)(H,32,38)(H,33,39,46)/b6-4+/t13?,14-,15-,18-,19-,20+,21-,22-,23-,24+,25-,26-,27-,28-,29-/m1/s1
InChI key	ZHSGGJXRNHWHRS-PEALBESXSA-N
Quality Level	200
SMILES string	N4(C=CC(=O)NC4=O)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)C(O)C[C@H]2O[C@@H]([C@@H]([C@H]([C@H]2O)O)NC(=O)C=CCC(C)C)O[C@H]3O[C@@H]([C@H]([C@@H]([C@H]3NC(=O)C)O)O)CO
storage temp.	2-8°C

Application:	Tunicamycin has been used to study the effect of N-linked glycosylation of human proton-coupled folate transporter (HsPCFT) in HeLa cells. Tunicamycin has also been used to study the functional effects of coxsackievirus and adenovirus receptor (CAR) glycosylation in COS-7 cells.
Biochem/physiol Actions:	Tunicamycin is an antibacterial and antifungal.
Biochem/physiol Actions:	Tunicamycin is an antibacterial and antifungal. Tunicamycin blocks the formation of protein N-glycosidic linkages by inhibiting the transfer of N-acetylglucosamine 1-phosphate to dolichol monophosphate. Tunicamycin inhibits bacterial and eukaryote N-acetylglucosamine transferases and prevents formation of N-acetylglucosamine lipid intermediates.
Biochem/physiol Actions:	Tunicamycin plays an important role in the antitumor activity of trastuzumab on breast cancer in vitro and in vivo. In human cell lines, tunicamycin enhances cytotoxicity stimulated by cisplatin. It prevents angiogenesis in nude mice by reducing the expression of vascular endothelial growth factor (VEGF).
General description:	Tunicamycin Ready Made Solution contains homologues A,B,C, and D. The composition may vary from lot to lot. Actual content given on label.
General description:	Tunicamycin was first isolated from Streptomyces lysosuperificus based on its antiviral activity. It contains N-acetylglucosamine and inhibits glycoprotein biosynthesis, including virus membrane glycoproteins.

WGK Germany	WGK 1
Flash Point(F)	188.6 °F
Flash Point(C)	87 °C

Storage Temp.	2-8°C
UNSPSC	51111800

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