TAPI-0

SIGMA/SML1292 - ≥95% (HPLC)

Synonym: N-(R)-(2-(Hydroxyaminocarbonyl)Methyl)-4-Methylpentanoyl-L-Naphthylalanyl-L-Alanine amide; TNF-α Processing Inhibitor-0; TNF-α Protease Inhibitor-0

CAS Number: 163958-73-4
Empirical Formula (Hill Notation): C₂₄H₃₂N₄O₅
Molecular Weight: 456.53
MDL Number: MFCD02684279
Linear Formula: C₂₄H₃₂N₄O₅
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML1292-1MG	1 mg	$396.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥95% (HPLC)
color	white to off-white
form	powder
InChI	1S/C24H32N4O5/c1-14(2)11-18(13-21(29)28-33)23(31)27-20(24(32)26-15(3)22(25)30)12-17-9-6-8-16-7-4-5-10-19(16)17/h4-10,14-15,18,20,33H,11-13H2,1-3H3,(H2,25,30)(H,26,32)(H,27,31)(H,28,29)/t15-,18+,20-/m0/s1
InChI key	WSJJYJNVFYARGB-CVAIRZPRSA-N
Quality Level	100
shipped in	wet ice
SMILES string	NC([C@@](C)([H])NC([C@]([H])(CC1=CC=CC2=C1C=CC=C2)NC([C@@](CC(C)C)([H])CC(NO)=O)=O)=O)=O
storage temp.	−20°C

Biochem/physiol Actions:	TAPI-0 inhibit peptide deformylase (PDF) activity and retard the growth Chlamydia trachomatis, which is an obligate intracellular bacterium responsible for a number of human diseases.
Biochem/physiol Actions:	TAPI-0 is a metalloproteinase inhibitor with selectivity for TACE (TNF-α converting enzyme/ADAM17; IC₅₀ = 100 nM). TAPI-0 also inhibits of collagenase and gelatinase. Although not specific for TACE, TAPI-0 is extensively used to block TACE-mediated TNF-α shedding.
Biochem/physiol Actions:	TAPI-0 is a metalloproteinase inhibitor with selectivity for TACE; also inhibits collagenase and gelatinase.
Packaging:	1 mg in glass bottle

Symbol	GHS06
Signal word	Danger
Hazard statements	H301
Precautionary statements	P301 + P310 + P330
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥95% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

To Order From a Quote