6-Thio-2′-Deoxyguanosine
SIGMA/SML1296 - ≥97% (HPLC)
Synonym: 2′-Ddeoxy-6-thio-guanosine; 2′-Deoxy-6-thioguanosine; 2′-Deoxythioguanosine; 2-Amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-mercaptopurine; 2-Amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-9H-purine-6(1H)-thione (7CI,8CI); 6-Thio-dG; NSC 71261
CAS Number: 789-61-7
Empirical Formula (Hill Notation): C10H13N5O3S
Molecular Weight: 283.31
Linear Formula: C10H13N5O3S
Product Type: Chemical
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This image depicts SML1296-25MG.
This image depicts SML1296-25MG.
| assay | ≥97% (HPLC) |
| color | white to brown |
| form | powder |
| InChI | 1S/C10H13N5O3S/c11-10-13- |
| InChI key | SCVJRXQHFJXZFZ-HSUXUTPPSA |
| Quality Level | 100  |
| SMILES string | S=C1C2=C(N([C@H]3C[C@H](O |
| solubility | DMSO: 5 mg/mL, clear (warmed) |
| storage temp. | −20°C |
| Application: | 6-Thio-2′-Deoxyguanosine has been used in secreted luciferase enzyme activity in tonsillar cancer cells. |
| Biochem/physiol Actions: | 6-Thio-2′-deoxyguanosine (6-thio-dG) is a nucleoside analog and telomerase substrate that is incorporated into de novo–synthesized telomeres. |
| Biochem/physiol Actions: | 6-Thio-2′-deoxyguanosine (6-thio-dG) is a nucleoside analog and telomerase substrate that is incorporated into de novo–synthesized telomeres. 6-Thio-2′-deoxyguanosine induces telomere dysfunction and rapid cell death in cancer cells, while spearing telomerase-negative cells. |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥97% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |