K02288
SIGMA/SML1307 - >98% (HPLC)
Synonym: 3-
CAS Number: 1431985-92-0
Empirical Formula (Hill Notation): C20H20N2O4
Molecular Weight: 352.38
MDL Number: MFCD26936347
Linear Formula: C20H20N2O4
Product Type: Chemical
| assay | >98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C20H20N2O4/c1-24-17-9- |
| InChI key | CJLMANFTWLNAKC-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | NC1=C(C2=CC(OC)=C(OC)C(OC |
| solubility | DMSO: 5 mg/mL, clear (warmed) |
| storage temp. | 2-8°C |
| Biochem/physiol Actions: | K02288 is a selective and potent inhibitor of the bone morphogenetic protein (BMP) type I receptor kinases with IC50s in the range 1–2 nM against ALK1 and ALK2. K02288 has IC50 values of 1.1, 1.8, 6.4 nM for ALK2, ALK1 and ALK6 respectively and IC50s of 34.4, 302, 321 and 220 nM for other ALKs (3, 4, 5) and ActRIIA. K02288 specifically inhibited the BMP-induced Smad pathway without affecting TGF-β signaling and induced dorsalization of zebrafish embryos. |
| Biochem/physiol Actions: | K02288 is a selective and potent inhibitor of the bone morphogenetic protein (BMP) type I receptor kinases. |
| Biochem/physiol Actions: | K02288 is functionally similar to dorsomorphin, which is known to be the first small-molecule for BMP signaling inhibition. BMP signalling is associated with many important physiological processes. It acts a central regulator of developmental processes such as organogenesis, gastrulation, mesoderm induction and endochondral bone formation. BMP signals are also related to diseases including pulmonary hypertension, juvenile polyposis syndrome, fibrodysplasia ossificans progressiva and hereditary hemorrhagic telangiectasia syndrome. BMP signaling inhibition might serve as a tool to study its role in other biological processes. |
| General description: | K02288 is a 2-aminopyridine compound. |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |   GHS05,GHS06 |
| Signal word | Danger |
| Hazard statements | H301 - H318 |
| Precautionary statements | P280 - P301 + P310 + P330 - P305 + P351 + P338 + P310 |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | >98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 51111800 |