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SQ109

SIGMA/SML1309 - ≥98% (HPLC)

Synonym: N-[(2E)-3,7-Dimethyl-2,6-octadienyl]-N′-tricyclo[3.3.1.13,7]dec-2-yl-1,2-ethanediamine; N-[(2E)-3,7-dimethyl-2,6-octadienyl]-NŒ-tricyclo[3.3.1.13,7]dec-2-yl-1,2-ethanediamine; NSC 722041

CAS Number: 502487-67-4
Empirical Formula (Hill Notation): C22H38N2
Molecular Weight: 330.55
Linear Formula: C22H38N2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1309-10MG 10 mg
 $349.00
1/EA		 Add To Favorites
45-SML1309-50MG 50 mg
 $1420.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color colorless to yellow
form oil
InChI 1S/C22H38N2/c1-16(2)5-4-6-17(3)7-8-23-9-10-24-22-20-12-18-11-19(14-20)15-21(22)13-18/h5,7,18-24H,4,6,8-15H2,1-3H3/b17-7+
InChI key JFIBVDBTCDTBRH-REZTVBANSA-N
Quality Level 100 
SMILES string C/C(CCC=C(C)C)=CCNCCNC1[C@@H]2C[C@@H]3C[C@H]1C[C@H](C2)C3
storage temp. 2-8°C
Application: SQ109 has been used:
• as an antitubercular agent to study its interactions with mycobacterial membrane proteins large 3 (MmpL3) binding pocket
•  as a positive control to determine the minimum inhibitory concentration (MIC) of ohmyungsamycins (OMS) A and B against Mycobacterium tuberculosis (Mtb) using the resazurin microtiter assay (REMA) plate method
•  as an inhibitor of MmpL3 to explore the utility of mycobacterial CRISPR interference for validating target gene essentiality and compound mode of action
Biochem/physiol Actions: Antitubercular; Inhibitor of MmpL3, a mycolic acid transporter required for incorporation of mycolic acid into the Mycobacterium tuberculosis cell wall.
Biochem/physiol Actions: SQ109 exhibits activity against Helicobacter pylori and the fungi Candida albicans. It might also possess anti-bacterial activity.
Biochem/physiol Actions: SQ109 is an antitubercular developed for the treatment of multidrug-resistant tuberculosis (MDR-TB). SQ109 inhibits the activity of MmpL3, a mycolic acid transporter required for incorporation of mycolic acid into the Mycobacterium tuberculosis cell wall.
General description: SQ109 is a 1,2-ethylenediamine, which is related to ethambutol.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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