NSC756093

SIGMA/SML1310 - ≥98% (HPLC)

Synonym: 4,9-Dihydro-4-(2-hydroxyethyl)-6-methoxy-9-phenyl-furo[3,4-b]quinolin-1(3H)-one; 4-(2-Hydroxyethyl)-6-methoxy-9-phenyl-4,9-dihydrofuro[3,4-b]quinolin-1(3H)-one

CAS Number: 1629908-92-4
Empirical Formula (Hill Notation): C₂₀H₁₉NO₄
Molecular Weight: 337.37
MDL Number: MFCD28902215
Linear Formula: C₂₀H₁₉NO₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML1310-5MG	5 mg	$111.00 1/EA	Add To Favorites
45-SML1310-25MG	25 mg	$295.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C20H19NO4/c1-24-14-7-8-15-16(11-14)21(9-10-22)17-12-25-20(23)19(17)18(15)13-5-3-2-4-6-13/h2-8,11,18,22H,9-10,12H2,1H3
InChI key	SMEJQLRLHKWIFV-UHFFFAOYSA-N
Quality Level	100
SMILES string	OCCN1C2=C(C(OC2)=O)C(C3=CC=CC=C3)C4=C1C=C(OC)C=C4
solubility	DMSO: 10 mg/mL, clear
storage temp.	2-8°C

Biochem/physiol Actions:	NSC756093, a podophyllotoxin analog, is a potent and specific inhibitor of GBP1:PIM1 interaction that inhibits proliferation of paclitaxel resistant cancer cells. Apparently, NSC756093 stabilizes a conformation of GBP1 not suitable for binding to PIM1.
Biochem/physiol Actions:	NSC756093, a podophyllotoxin analog, is a potent and specific inhibitor of GBP1:PIM1 interaction.
Packaging:	5, 25 mg in glass bottle

Symbol	GHS07,GHS09
Signal word	Warning
Hazard statements	H302 - H400
Precautionary statements	P273 - P301 + P312 + P330 - P391
RIDADR	UN 3077 9 / PGIII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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