Rubone
SIGMA/SML1311 - ≥98% (HPLC)
Synonym: (2E)
CAS Number: 73694-15-2
Empirical Formula (Hill Notation): C20H22O7
Molecular Weight: 374.38
Linear Formula: C20H22O7
Product Type: Chemical
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This image depicts SML1311-5MG.
This image depicts SML1311-5MG.
| assay | ≥98% (HPLC) |
| color | yellow to orange |
| form | powder |
| InChI | 1S/C20H22O7/c1-23-13-9-15 |
| InChI key | VHCQVGQULWFQTM-VOTSOKGWSA |
| Quality Level | 100  |
| SMILES string | O(C)c1c(cc(c(c1)OC)C=CC |
| solubility | DMSO: 2 mg/mL, clear (warmed) |
| storage condition | desiccated |
| storage temp. | 2-8°C |
| Biochem/physiol Actions: | Rubone has strong anticancer activity. Rubone and paclitaxel (PTX) combination therapy retarded cancer cell growth, migration and cancer stem-like cells (CSC) population growth. |
| Biochem/physiol Actions: | Rubone is a miR34a modulator that specifically restores miR34a in hepatocellular carcinoma cells with wild-type or mutated p53. Rubone potently inhibits growth of hepatocellular carcinoma in a mouse xenograft model. Rubone does not effect the growth of nontumorigenic human hepatocytes. |
| Biochem/physiol Actions: | Rubone is a miR34a modulator that specifically restores miR34a in hepatocellular carcinoma cells. |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |