BMS 204352

SIGMA/SML1313 - ≥98% (HPLC)

Synonym: (3S)-(+)-(5-Chloro-2-methoxyphenyl)-1,3-dihydro-3-fluoro-6-(trifluoromethyl)-2H-indole-2-one

CAS Number: 187523-35-9
Empirical Formula (Hill Notation): C₁₆H₁₀ClF₄NO₂
Molecular Weight: 359.70
MDL Number: MFCD09475617
Linear Formula: C₁₆H₁₀ClF₄NO₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML1313-5MG	5 mg	$161.00 1/EA	Add To Favorites
45-SML1313-25MG	25 mg	$796.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C16H10ClF4NO2/c1-24-13-5-3-9(17)7-11(13)15(18)10-4-2-8(16(19,20)21)6-12(10)22-14(15)23/h2-7H,1H3,(H,22,23)/t15-/m0/s1
InChI key	ULYONBAOIMCNEH-HNNXBMFYSA-N
Quality Level	100
SMILES string	O=C1NC2=CC(C(F)(F)F)=CC=C2[C@@]1(C3=CC(Cl)=CC=C3OC)F
solubility	DMSO: 20 mg/mL, clear
storage temp.	−20°C

Application:	BMS 204352 has been used in drug administration.
Biochem/physiol Actions:	BMS 204352 (MaxiPost [(3S)-(+)-(5-chloro-2-methoxyphenyl)-1,3-dihydro-3-fluoro-6-(trifluoromethyl)-2H-indole-2-one)] is used to treat ischemic stroke. It also acts as an activator of KNCQ4 (KQT-like subfamily, member 4) and KCNQ5 (KQT-like subfamily, member 5) with equal potency.
Biochem/physiol Actions:	BMS 204352 is a potassium channel modulator.
Biochem/physiol Actions:	BMS 204352 is a potassium channel modulator. Originally developed as a potent opener of large-conductance, calcium-activated (Maxi-K, KCa1.1, BK) potassium channels, BMS 204352 also acts as a positive modulator at Kv7 (KCNQ) channels.
Packaging:	5, 25 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H315 - H319 - H335
Precautionary statements	P302 + P352 - P305 + P351 + P338
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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