SAG dihydrochloride

SIGMA/SML1314 - ≥98% (HPLC)

Synonym: 3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]-benzo[b]thiophene-2-carboxamide dihydrochloride; Smoothened Agonist

CAS Number: 912545-86-9 (free base)
Empirical Formula (Hill Notation): C₂₈H₂₈ClN₃OS · 2HCl
Molecular Weight: 562.98
Linear Formula: C₂₈H₂₈ClN₃OS · 2HCl
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML1314-1MG	1 mg	$129.00 1/EA	Add To Favorites
45-SML1314-5MG	5 mg	$509.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	lyophilized solid
InChI	1S/C28H28ClN3OS/c1-30-22-9-11-23(12-10-22)32(28(33)27-26(29)24-7-2-3-8-25(24)34-27)18-19-5-4-6-21(17-19)20-13-15-31-16-14-20/h2-8,13-17,22-23,30H,9-12,18H2,1H3/t22-,23-
InChI key	VFSUUTYAEQOIMW-YHBQERECSA-N
Quality Level	100
SMILES string	O=C(C1=C(Cl)C2=C(C=CC=C2)S1)N([C@@]3([H])CC[C@@](NC)([H])CC3)CC4=CC(C5=CC=NC=C5)=CC=C4
solubility	H₂O: 20 mg/mL, clear
storage condition	desiccated
storage temp.	−20°C

Application:	Smoothened agonist (SAG) dihydrochloride has been used as a sonic hedgehog (SHH) pathway agonist: • to study its effects on mouse hippocampal cells • to determine its effects on the mitochondrial network in zebrafish embryo • to study its effects on murine embryonic fibroblasts
Biochem/physiol Actions:	SAG is a potent and cell-permeable smoothened (Smo) agonist that activates Hedgehog pathway and counteracts Cyclopamine inhibition of Smo.
Biochem/physiol Actions:	SAG is a potent and cell-permeable smoothened (Smo) agonist.
Packaging:	1, 5 mg in glass bottle

Symbol	GHS06
Signal word	Danger
Hazard statements	H301 - H413
Precautionary statements	P273 - P301 + P310 + P330
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	51111800

To Order From a Quote