Synonym: (3R)-2′-[(4-Bromo-2-fluorophenyl)methyl]-spiro[pyrrolidine-3,4′(1′H)-pyrrolo[1,2-a]pyrazine]-1′,2,3′,5(2′H)-tetrone.; AS-3201
CAS Number: 147254-64-6
Empirical Formula (Hill Notation): C17H11BrFN3O4
Molecular Weight: 420.19
MDL Number: MFCD00920915
Linear Formula: C17H11BrFN3O4
Product Type: Chemical
| assay |
≥97% (HPLC) |
| color |
white to beige |
| form |
powder |
| InChI |
1S/C17H11BrFN3O4/c18-10-4-3-9(11(19)6-10)8-21-14(24)12-2-1-5-22(12)17(16(21)26)7-13(23)20-15(17)25/h1-6H,7-8H2,(H,20,23,25)/t17-/m1/s1 |
| InChI key |
QCVNMNYRNIMDKV-QGZVFWFLSA-N |
| optical activity |
[α]/D -5 to -10°, c = 1.0 in methanol |
| Quality Level |
100  |
| SMILES string |
O=C(N1CC2=C(F)C=C(Br)C=C2)C3=CC=CN3[C@@]4(CC(NC4=O)=O)C1=O |
| solubility |
DMSO: 20 mg/mL, clear |
| storage temp. |
−20°C |
| Biochem/physiol Actions: |
Ranirestat (AS-3201) is an aldose reductase (AR) inhibitor. |
| Biochem/physiol Actions: |
Ranirestat (AS-3201) is an aldose reductase (AR) inhibitor. Aldose reductase is a rate-limiting enzyme in the conversion of D-glucose to fructose via D-sorbitol. Ranirestat has been implicated in diabetic complications (cataract formation, retinopathy, neuropathy, nephropathy). Ranirestat prevents sorbitol accumulation and is thus hoped to be effective in the remedy of diabetic neuropathy. |
| Packaging: |
5, 25 mg in glass bottle |
| Purity |
≥97% (HPLC) |
| Storage Temp. |
−20°C |
| UNSPSC |
12352200 |
GHS07