XAP044

SIGMA/SML1317 - ≥98% (HPLC)

Synonym: 7-Hydroxy-3-(4-iodophenoxy)-4H-chromen-4-one; XAP 044

CAS Number: 196928-50-4
Empirical Formula (Hill Notation): C₁₅H₉IO₄
Molecular Weight: 380.13
MDL Number: MFCD00525548
Linear Formula: C₁₅H₉IO₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SML1317-25MG	25 mg	$399.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C15H9IO4/c16-9-1-4-11(5-2-9)20-14-8-19-13-7-10(17)3-6-12(13)15(14)18/h1-8,17H
InChI key	XXZKJJYWINSUMJ-UHFFFAOYSA-N
Quality Level	100
SMILES string	O=C1C(OC2=CC=C(I)C=C2)=COC3=C1C=CC(O)=C3
solubility	DMSO: 20 mg/mL, clear
storage condition	protect from light
storage temp.	2-8°C

Biochem/physiol Actions:	XAP044 is a brain penetrant, potent and selective mGlu7 (metabotropic glutamate receptor subtype 7) antagonist that inhibits lateral amygdala long-term potentiation (LTP) in brain slices from wild type mice. XAP044 binds to a pocket localized in mGlu7’s extracellular Venus flytrap domain (VFTD) close to the binding site of the orthosteric agonist L-glutamate. XAP044 exhibits a wide-spectrum anti-stress, antidepressant- and anxiolytic-like efficacy in rodent behavioral model.
Biochem/physiol Actions:	XAP044 is a brain penetrant, potent and selective mGlu7 antagonist.
Other Notes:	Light sensitive. This compound has Iodine and should be kept in the dark.
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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