ETP-46464
SIGMA/SML1321 - ≥98% (HPLC)
Synonym: 2-
CAS Number: 1345675-02-6
Empirical Formula (Hill Notation): C30H22N4O2
Molecular Weight: 470.52
MDL Number: MFCD23160051
Linear Formula: C30H22N4O2
Product Type: Chemical
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SML1321-5MG.
This image depicts SML1321-5MG.
| assay | ≥98% (HPLC) |
| color | white to light brown |
| form | powder |
| InChI | 1S/C30H22N4O2/c1-30(2,18- |
| InChI key | DPLMXAYKJZOTKO-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | CC(C)(C#N)C(C=C1)=CC=C1N( |
| solubility | DMSO: 2 mg/mL, clear (warmed) |
| storage temp. | −20°C |
| Biochem/physiol Actions: | ETP-46464 is a potent and selective inhibitor of the DNA damage response kinase Ataxia telangiectasia-mutated (ATM) - and Rad3-related (ATR) with an IC50 of 25 nM. ETP-46464 shows moderate activity against PI3K and is a potent inhibitor of mTor, but is selective for ATR versus ATM and DNA -dependent protein kinase (DNA -PKcs) even at high doses. ETP-46464 inhibited phosphorylation of Chk1, the downstream kinase of ATR, but did not affect ionizing radiation–induced γH2AX formation, which is jointly controlled by ATM and DNA-PKc. |
| Biochem/physiol Actions: | ETP-46464 is a potent and selective inhibitor of the DNA damage response kinase Ataxia telangiectasia-mutated (ATM) - and Rad3-related (ATR). |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |