NU6140

SIGMA/SML1323 - ≥98% (HPLC)

Synonym: 4-[[6-(Cyclohexylmethoxy)-9H-purin-2-yl]amino]-N,N-diethyl-benzamide

CAS Number: 444723-13-1
Empirical Formula (Hill Notation): C₂₃H₃₀N₆O₂
Molecular Weight: 422.52
MDL Number: MFCD09264153
Linear Formula: C₂₃H₃₀N₆O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SML1323-5MG	5 mg	$122.00 1/EA		Add To Favorites
45-SML1323-25MG	25 mg	$501.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C23H30N6O2/c1-3-29(4-2)22(30)17-10-12-18(13-11-17)26-23-27-20-19(24-15-25-20)21(28-23)31-14-16-8-6-5-7-9-16/h10-13,15-16H,3-9,14H2,1-2H3,(H2,24,25,26,27,28)
InChI key	XHEQSRJCJTWWAH-UHFFFAOYSA-N
Quality Level	100
SMILES string	O=C(N(CC)CC)C1=CC=C(NC2=NC(NC=N3)=C3C(OCC4CCCCC4)=N2)C=C1
solubility	DMSO: 20 mg/mL, clear
storage temp.	2-8°C

Application:	NU6140 has been used to study its effect on transcription factors NANOG, OCT4 (organic cation/carnitine transporter 4) and SOX2(SRY-box 2), involved in pluripotency of human embryonic stem (hES) cells and embryonal carcinoma-derived (hEC) cells.
Biochem/physiol Actions:	NU6140 is a CDK2 inhibitor with 10-36-fold selectivity over other CDK family members. NU6140 induces apoptosis and cell cycle arrest in cancer cells in the G2-M phase, and potentiates the cytotoxic effects of paclitaxel.
Biochem/physiol Actions:	NU6140 is a CDK2 inhibitor.
Biochem/physiol Actions:	NU6140 is known to downregulate the expression of survivin protein, which possesses antiapoptotic activity and is generally overexpressed in cancer cells.
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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