XEN445

SIGMA/SML1324 - ≥98% (HPLC)

Synonym: (S)-2-(3-(Pyridin-2-ylmethoxy)pyrrolidin-1-yl)-5-(trifluoromethyl)benzoic acid

CAS Number: 1515856-92-4
Empirical Formula (Hill Notation): C₁₈H₁₇F₃N₂O₃
Molecular Weight: 366.33
Linear Formula: C₁₈H₁₇F₃N₂O₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML1324-5MG	5 mg	$88.30 1/EA	Add To Favorites
45-SML1324-25MG	25 mg	$433.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C18H17F3N2O3/c19-18(20,21)12-4-5-16(15(9-12)17(24)25)23-8-6-14(10-23)26-11-13-3-1-2-7-22-13/h1-5,7,9,14H,6,8,10-11H2,(H,24,25)/t14-/m0/s1
InChI key	NBGRERFNOKZQLO-AWEZNQCLSA-N
Quality Level	100
SMILES string	FC(F)(F)c1cc(c(cc1)N2C[C@H](CC2)OCc3ncccc3)C(=O)O
solubility	DMSO: 10 mg/mL, clear
storage temp.	2-8°C

Biochem/physiol Actions:	XEN445 is a potent and selective inhibitor of endothelial lipase with an IC₅₀ of 237 nM and high selectivity over hepatic and lipoprotein lipases. In experiments with wild-type mice, XEN445 raised plasma HDL-cholesterol levels by 16% after 3 days and by 30% after 9 days dosing.
Biochem/physiol Actions:	XEN445 is a potent and selective inhibitor of endothelial lipase.
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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