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Glutaminase Inhibitor 968

SIGMA/SML1327 - ≥98% (HPLC)

Synonym: 5-(3-Bromo-4-(dimethylamino)phenyl)-2,2-dimethyl-2,3,5,6-tetrahydrobenzo[a]phenanthridin-4(1H)-one

CAS Number: 311795-38-7
Empirical Formula (Hill Notation): C27H27BrN2O
Molecular Weight: 475.42
Linear Formula: C27H27BrN2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1327-5MG 5 mg
 $129.00
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45-SML1327-25MG 25 mg
 $509.00
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This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C27H27BrN2O/c1-27(2)14-19-24-18-8-6-5-7-16(18)9-11-21(24)29-26(25(19)23(31)15-27)17-10-12-22(30(3)4)20(28)13-17/h5-13,26,29H,14-15H2,1-4H3
InChI key NVFRRJQWRZFDLM-UHFFFAOYSA-N
Quality Level 100 
SMILES string Brc1c(ccc(c1)C2Nc3c(c5c(cc3)cccc5)C4=C2C(=O)CC(C4)(C)C)N(C)C
solubility DMSO: 5 mg/mL, clear (warmed)
storage temp. 2-8°C
Application: Glutaminase inhibitor 968 has been used to study the role of glutamine metabolism in macrophage activation.
Biochem/physiol Actions: Glutaminase Inhibitor 968 is an allosteric inihibitor of the mitochondrial enzyme glutaminase C (GAC), which is overexpressed in a number of cancer cell lines. Glutaminase Inhibitor 968 shows 21% inhibition at 10 μM, 94% at 25 μM. Glutaminase Inhibitor 968 blocked human cancer cell proliferation in culture, and in inhibited tumor formation in mouse xenograft models.
Biochem/physiol Actions: Glutaminase Inhibitor 968 is an allosteric inihibitor of the mitochondrial enzyme glutaminase C (GAC).
Biochem/physiol Actions: Variation in the 3-bromo-4-(dimethylamino)phenyl ring of glutaminase inhibitor 968, leads to loss of its inhibitory activity. Glutaminase catalysed glutamine metabolism maintains intracellular pH of cancer cells. Inhibition by glutaminase inhibitor 968 is known to hinder cell proliferation as a consequences of low intracellular pH.
General description: Glutaminase Inhibitor 968 belongs to the benzophenanthridinone family.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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