MLS1547

SIGMA/SML1331 - ≥98% (HPLC)

Synonym: 5-Chloro-7-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-8-quinolinol; MLS000051547

CAS Number: 315698-36-3
Empirical Formula (Hill Notation): C₁₉H₁₉ClN₄O
Molecular Weight: 354.83
MDL Number: MFCD02330713
Linear Formula: C₁₉H₁₉ClN₄O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML1331-5MG	5 mg	$107.00 1/EA	Add To Favorites
45-SML1331-25MG	25 mg	$421.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C19H19ClN4O/c20-16-12-14(19(25)18-15(16)4-3-7-22-18)13-23-8-10-24(11-9-23)17-5-1-2-6-21-17/h1-7,12,25H,8-11,13H2
InChI key	OPEJNANYABTIGC-UHFFFAOYSA-N
Quality Level	100
SMILES string	OC1=C(CN2CCN(C3=NC=CC=C3)CC2)C=C(Cl)C4=CC=CN=C41
solubility	DMSO: 5 mg/mL, clear (warmed)
storage temp.	2-8°C

Biochem/physiol Actions:	MLS1547 is a highly efficacious D2 dopamine receptor (D2R) G protein-biased agonist that does not recruit β-arrestin, and is an antagonist of dopamine-stimulated β-arrestin recruitment to the D2 receptor. MLS-1547 is the first D2 receptor agonist with close to full efficacy for G protein signaling (EC₅₀ = 370 nM), but no ability to recruit β-arrestin.
Biochem/physiol Actions:	MLS1547 is a highly efficacious D2 dopamine receptor (D2R) G protein-biased agonist.
Packaging:	5, 25 mg in glass bottle

Symbol	GHS06
Signal word	Danger
Hazard statements	H301
Precautionary statements	P301 + P310 + P330
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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