Advanced Search



NG25 trihydrochloride

SIGMA/SML1332 - ≥98% (HPLC)

Synonym: N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-benzamide trihydrochloride; NG 25 trihydrochloride

CAS Number: 1315355-93-1 (free base)
Empirical Formula (Hill Notation): C29H30F3N5O2 · 3HCl
Molecular Weight: 646.96
MDL Number: MFCD19443255
Linear Formula: C29H30F3N5O2 · 3HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1332-5MG 5 mg
 $162.00
1/EA		 Add To Favorites
45-SML1332-25MG 25 mg
 $649.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C29H30F3N5O2/c1-3-36-12-14-37(15-13-36)18-21-6-7-22(17-24(21)29(30,31)32)35-28(38)20-5-4-19(2)26(16-20)39-25-9-11-34-27-23(25)8-10-33-27/h4-11,16-17H,3,12-15,18H2,1-2H3,(H,33,34)(H,35,38)
InChI key SMPGEBOIKULBCT-UHFFFAOYSA-N
Quality Level 100 
SMILES string CC1=CC=C(C(NC2=CC=C(CN3CCN(CC)CC3)C(C(F)(F)F)=C2)=O)C=C1OC4=C(C=CN5)C5=NC=C4
solubility H2O: 5 mg/mL, clear
storage condition protect from light
storage temp. 2-8°C
Application: NG25 trihydrochloride has been used as a transforming growth factor β (TGFβ)-activated kinase 1 inhibitor (TAK1) in human umbilical vein endothelial cells (HUVECs) and pulmonary artery smooth muscle cells.
Biochem/physiol Actions: NG25 is multiple kinase inhibitor; potent dia; omjobotpr pf TAK1 and MAP4K2 kinases.
Biochem/physiol Actions: NG25 is potent multiple kinase inhibitor belonging to type II kinase inhibitors class that binds to kinase ATP binding pocket at not ready to catalyze conformation. NG25 is used as a potent dual inhibitor of TAK1 (TGFβ-Activated Kinase 1, MAP3K7) and MAP4K2 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2; GCK) kinases. NG25 inhibits the activation of IKKa/IKKb and prevents the secretion of type 1 IFNs by TLR2 and TLR9 agonist.
Other Notes: Light sensitive
Packaging: 5, 25 mg in glass bottle
Symbol GHS06  GHS06
Signal word Danger
Hazard statements H301 - H413
Precautionary statements P273 - P301 + P310 + P330
RIDADR UN 2811 6.1 / PGIII
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

The following items have been added to your cart:

Choose a favorite list for this item:
Catalog Number Description Price
$

Returns/Order support

Please fill out the form below if you want to request order support from Krackeler Scientific.


Quick Order

* Required


New Year Price Updates

We are currently working diligently to update our website pricing information for the New Year. If you place an order, you will be acknowledged with any corrected pricing. If you'd like the most current information sooner, please don't hesitate to drop us an email or give us a call and we'd be happy to assist. Thank you for your patience while we are updating.

800-334-7725
office@krackeler.com


Play Video

To Request a Quote

  1. Search or Browse for items and add to them to your Shopping Cart.
  2. Click the "Request Quote" button at the bottom of the Shopping Cart page.
  3. Fill out required fields.
  4. Optionally you can convert to standard checkout mode by choosing a payment type.
  5. Click "Request Quote" at the bottom of the page.

You will be contacted with a quote.

To Order From a Quote

  1. Register and login to the website.
  2. Receive a quote from your sales representative or customer service.
  3. Have your copy of the quote in hand.
  4. Visit our quote module to search for your quote.
Back to Top