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NQ301

SIGMA/SML1337 - ≥98% (HPLC)

Synonym: 2-Chloro-3-(4-acetophenyl)-amino-1,4-naphthoquinone; 2-[(4-Acetylphenyl)amino]-3-chloro-1,4-naphthalenedione; Compound 211; NQ 301

CAS Number: 130089-98-4
Empirical Formula (Hill Notation): C23H19N3O · HBr
Molecular Weight: 434.33
MDL Number: MFCD00559986
Linear Formula: C23H19N3O · HBr
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1337-5MG 5 mg
 $129.00
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45-SML1337-25MG 25 mg
 $388.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color , faint red to dark red
form powder
InChI 1S/C18H12ClNO3/c1-10(21)11-6-8-12(9-7-11)20-16-15(19)17(22)13-4-2-3-5-14(13)18(16)23/h2-9,20H,1H3
InChI key LSQZKIQSQHZVQS-UHFFFAOYSA-N
Quality Level 100 
SMILES string O=C1C(Cl)=C(NC2=CC=C(C(C)=O)C=C2)C(C3=CC=CC=C31)=O
solubility DMSO: 10 mg/mL, clear
storage temp. 2-8°C
Biochem/physiol Actions: NQ301 is an antithrombotic agent. Recent study shows that NQ301 (Compound 211) is a highly potent, selective, non-competitive allosteric inhibitor of CD45 that selectively inhibits dephosphorylation of substrate Lck pY-505 versus Lck pY-393. NQ301 prevents T cell receptor-mediated activation of Lck, Zap-70 and MAPK, and IL-2 production in primary T-cells. NQ301 exhibits immunosuppressive activity in mice.
Biochem/physiol Actions: NQ301 is an antithrombotic agent; antiplatelet; highly potent, selective non-competitive allosteric inhibitor of CD45.
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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