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AR420626

SIGMA/SML1339 - ≥98% (HPLC)

Synonym: AR 420626; N-(2,5-Dichlorophenyl)-4-(furan-2-yl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydro-quinoline-3-carboxamide

CAS Number: 1798310-55-0
Empirical Formula (Hill Notation): C21H18Cl2N2O3
Molecular Weight: 417.29
MDL Number: MFCD28987470
Linear Formula: C21H18Cl2N2O3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1339-5MG 5 mg
 $126.00
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45-SML1339-25MG 25 mg
 $509.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SML1339-5MG.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C21H18Cl2N2O3/c1-11-18(21(27)25-15-10-12(22)7-8-13(15)23)20(17-6-3-9-28-17)19-14(24-11)4-2-5-16(19)26/h3,6-10,20,24H,2,4-5H2,1H3,(H,25,27)
InChI key GGTYQECCGLBHGS-UHFFFAOYSA-N
Quality Level 100 
SMILES string ClC1=CC(NC(C2=C(C)NC(CCCC3=O)=C3C2C4=CC=CO4)=O)=C(Cl)C=C1
solubility DMSO: 5 mg/mL, clear (warmed)
storage temp. 2-8°C
Biochem/physiol Actions: AR420626 is a selective agonist of Free Fatty Acid 3 receptor FFA3 (previously called GPR41).
Biochem/physiol Actions: AR420626 is a selective agonist of Free Fatty Acid 3 receptor FFA3 (previously called GPR41). FFA3 is expressed in adipose tissue, gut, and the peripheral nervous system and normally activated by short chain fatty acids (SCFAs) produced in the body through the fermentation of complex carbohydrates by the gut microbiota. There is increasing interest in the role of the various free fatty acid receptors and SCFAs as chemical messengers in energy regulation and regulation of inflammatory processes and as therapeutic targets in the treatment of various metabolic and inflammatory conditions. AR420626 has an EC50 value of 117 nM for FFAR3 and did not activate FFAR2 in concentrations up to 100 μM.
Packaging: 5, 25 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Precautionary statements P301 + P312 + P330
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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