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API-1

SIGMA/SML1342

Synonym: 4-Amino-5,8-dihydro-5-oxo-8-b-D-ribofuranosyl-pyrido[2,3-d]pyrimidine-6-carboxamide; NSC 177223; NSC177223

CAS Number: 36707-00-3
Empirical Formula (Hill Notation): C13H15N5O6
Molecular Weight: 337.29
MDL Number: MFCD18086904
Linear Formula: C13H15N5O6
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1342-5MG 5 mg
 $149.00
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assay ≥95% (HPLC)
color white to beige
form powder
InChI 1S/C13H15N5O6/c14-10-6-7(20)4(11(15)23)1-18(12(6)17-3-16-10)13-9(22)8(21)5(2-19)24-13/h1,3,5,8-9,13,19,21-22H,2H2,(H2,15,23)(H2,14,16,17)/t5-,8-,9-,13-/m1/s1
InChI key SPBWHPXCWJLQRU-FITJORAGSA-N
Quality Level 100 
SMILES string O=C1C(C(N)=O)=CN([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)C3=C1C(N)=NC=N3
solubility DMSO: 1 mg/mL, clear (warmed)
storage temp. −20°C
Biochem/physiol Actions: API-1 is a potent and specific Akt/PKB inhibitor.
Biochem/physiol Actions: API-1 is a potent and specific Akt/PKB inhibitor. API-1 binds to pleckstrin homology (PH) domain of Akt and blocks Akt membrane translocation. The compound inhibits all three members of the family Akt1/PKBa, Akt2/PKBb and Akt3/PKBg. API-1 does not inhibit the activation of PKC, SGK, PKA, STAT3, Erk-1/2 or JNK.
Packaging: 5, 25 mg in glass bottle
Symbol GHS06  GHS06
Signal word Danger
Hazard statements H301
Precautionary statements P301 + P310 + P330
RIDADR UN 2811 6.1 / PGIII
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥95% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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