API-1
SIGMA/SML1342
Synonym: 4-
CAS Number: 36707-00-3
Empirical Formula (Hill Notation): C13H15N5O6
Molecular Weight: 337.29
MDL Number: MFCD18086904
Linear Formula: C13H15N5O6
Product Type: Chemical
assay | ≥95% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C13H15N5O6/c14-10-6-7( |
InChI key | SPBWHPXCWJLQRU-FITJORAGSA |
Quality Level | 100 |
SMILES string | O=C1C(C(N)=O)=CN([C@@H]2O |
solubility | DMSO: 1 mg/mL, clear (warmed) |
storage temp. | −20°C |
Biochem/physiol Actions: | API-1 is a potent and specific Akt/PKB inhibitor. API-1 binds to pleckstrin homology (PH) domain of Akt and blocks Akt membrane translocation. The compound inhibits all three members of the family Akt1/PKBa, Akt2/PKBb and Akt3/PKBg. API-1 does not inhibit the activation of PKC, SGK, PKA, STAT3, Erk-1/2 or JNK. |
Packaging: | 5, 25 mg in glass bottle |
Symbol | GHS06 |
Signal word | Danger |
Hazard statements | H301 |
Precautionary statements | P301 + P310 + P330 |
RIDADR | UN 2811 6.1 / PGIII |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥95% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |