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3PO

SIGMA/SML1343 - ≥98% (HPLC)

Synonym: (2E)-3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-one; 3PO (inhibitor of glucose metabolism)

CAS Number: 18550-98-6
Empirical Formula (Hill Notation): C13H10N2O
Molecular Weight: 210.23
MDL Number: MFCD00224002
Linear Formula: C13H10N2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1343-5MG 5 mg
 $76.50
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45-SML1343-25MG 25 mg
 $294.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C13H10N2O/c16-13(12-5-8-14-9-6-12)4-3-11-2-1-7-15-10-11/h1-10H/b4-3+
InChI key UOWGYMNWMDNSTL-ONEGZZNKSA-N
Quality Level 100 
SMILES string O=C(C1=CC=NC=C1)/C=C/C2=CN=CC=C2
solubility DMSO: 5 mg/mL, clear (warmed)
storage temp. 2-8°C
Application: 3PO has been used as a 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoform 3(PFKFB3) inhibitor to study its effect on cell viability loss, apoptosis, and necroptosis in colorectal cancer cells. It has also been used as a PFKFB3 inhibitor to inhibit glycolysis and study its effects on cell viability and reactive oxygen species (ROS) production in trabectedin (TRB) and lurbinectedin (LUR) treated human macrophages (hMFs).
Biochem/physiol Actions: 3PO is a potent and selective inhibitor of PFKFB3 (6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase) that reduces glycolytic flux and suppresses glucose uptake. 3PO is selectively cytostatic to transformed cells and suppresses the growth of established tumor in mice.
Biochem/physiol Actions: Inhibition of glycolysis by PFKFB3 blockade mediated by 3PO reduced pathological angiogenesis in cancer and inflammation. 3PO aids in the regulation of endothelial proliferation and migration. It also reduces pro-inflammatory activation of endothelial cells and experimental inflammation in vivo. Therefore, it may be a potential therapeutic for treating chronic inflammation. Its anti-inflammatory activity in human endothelial cells is independent of its target PFKFB3.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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