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BRD32048

SIGMA/SML1346 - ≥98% (HPLC)

Synonym: BRD 32048; N2-(4-Methoxyphenyl)-6-(1-piperidinylmethyl)-1,3,5-triazine-2,4-diamine

CAS Number: 433694-46-3
Empirical Formula (Hill Notation): C16H22N6O
Molecular Weight: 314.39
MDL Number: MFCD03190440
Linear Formula: C16H22N6O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1346-5MG 5 mg
 $111.00
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45-SML1346-25MG 25 mg
 $433.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SML1346-25MG.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C16H22N6O/c1-23-13-7-5-12(6-8-13)18-16-20-14(19-15(17)21-16)11-22-9-3-2-4-10-22/h5-8H,2-4,9-11H2,1H3,(H3,17,18,19,20,21)
InChI key PVHJDJWPRZUURH-UHFFFAOYSA-N
Quality Level 100 
SMILES string NC1=NC(NC2=CC=C(OC)C=C2)=NC(CN3CCCCC3)=N1
solubility DMSO: 20 mg/mL, clear
storage temp. 2-8°C
Biochem/physiol Actions: BRD32048 is a derivative of [1,3,5]triazine. It is found in orally active phosphodiesterase inhibitors (PDE) inhibitors, DHFR (dihydrofolate reductase) inhibitors and phosphatidylinositol-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitors. BRD32048 binds ETS variant 1 (ETV1) and controls transcriptional activity, facilitated by ETV1 and invasion of ETV1-driven cancer cells.
Biochem/physiol Actions: BRD32048 is a potent inhibitor of ETV1 (ETS variant 1) transcription factor oncoprotein.
Biochem/physiol Actions: BRD32048 is a potent inhibitor of ETV1 (ETS variant 1) transcription factor oncoprotein. BRD32048 binds ETV1 directly, modulating both ETV1-mediated transcriptional activity and invasion of ETV1-driven cancer cells.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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