Alvimopan

SIGMA/SML1347 - ≥98% (HPLC)

Synonym: ADL-8-2698; LY-246736; N-[(2S)-2-[[(3R,4R)-4-(3-Hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenylpropyl]glycine

CAS Number: 156053-89-3
Empirical Formula (Hill Notation): C₂₅H₃₂N₂O₄
Molecular Weight: 424.53
MDL Number: MFCD09838268
Linear Formula: C₂₅H₃₂N₂O₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML1347-5MG	5 mg	$118.00 1/EA	Add To Favorites
45-SML1347-25MG	25 mg	$462.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C25H32N2O4/c1-18-16-27(12-11-25(18,2)21-9-6-10-22(28)14-21)17-20(24(31)26-15-23(29)30)13-19-7-4-3-5-8-19/h3-10,14,18,20,28H,11-13,15-17H2,1-2H3,(H,26,31)(H,29,30)/t18-,20-,25+/m0/s1
InChI key	UPNUIXSCZBYVBB-JVFUWBCBSA-N
optical activity	[α]/D +46 to +52°, c = 1.0 in DMSO
Quality Level	100
SMILES string	C[C@H]1CN(C[C@@H](C(NCC(O)=O)=O)CC2=CC=CC=C2)CC[C@]1(C3=CC=CC(O)=C3)C
solubility	DMSO: 10 mg/mL, clear
storage temp.	2-8°C

Biochem/physiol Actions:

Alvimopan is a gastroprokinetic peripheral mu-opioid receptor antagonist. As a drug, Alvimopan is given to patients undergoing bowel surgery to protect the bowel from the effects of opioid medications that are used to treat pain, blocking the undesirable GI side-effects of the opioid agonists without affecting analgesia or causing withdrawal. Alvimopan does not cross the blood-brain barrier, competitively binding to gastrointestinal tract mu-opioid receptors.

Packaging:

5, 25 mg in glass bottle

Symbol	GHS07,GHS09
Signal word	Warning
Hazard statements	H315 - H319 - H400
Precautionary statements	P273 - P302 + P352 - P305 + P351 + P338
RIDADR	UN 3077 9 / PGIII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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