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STF-118804

SIGMA/SML1348 - ≥98% (HPLC)

Synonym: 4-(5-Methyl-4-(tosylmethyl)oxazol-2-yl)-N-(pyridin-3-ylmethyl)benzamide; 4-[5-Methyl-4-[[(4-methylphenyl)sulfonyl]methyl]-2-oxazolyl]-N-(3-pyridinylmethyl)-benzamide; STF 118804

CAS Number: 894187-61-2
Empirical Formula (Hill Notation): C25H23N3O4S
Molecular Weight: 461.53
MDL Number: MFCD14918065
Linear Formula: C25H23N3O4S
Product Type: Chemical

Catalog Number PKG Qty. Price Quantity
45-SML1348-5MG 5 mg
$118.00
1/EA
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45-SML1348-25MG 25 mg
$462.00
1/EA
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assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C25H23N3O4S/c1-17-5-11-22(12-6-17)33(30,31)16-23-18(2)32-25(28-23)21-9-7-20(8-10-21)24(29)27-15-19-4-3-13-26-14-19/h3-14H,15-16H2,1-2H3,(H,27,29)
InChI key DLFCEZOMHBPDGI-UHFFFAOYSA-N
Quality Level 100 
SMILES string O=C(C1=CC=C(C2=NC(CS(=O)(C3=CC=C(C)C=C3)=O)=C(C)O2)C=C1)NCC4=CN=CC=C4
solubility DMSO: 20 mg/mL, clear
storage temp. 2-8°C
Biochem/physiol Actions: STF-118804 displays pancreatic ductal adenocarcinoma (PDAC) growth reducing potential in combination with chemotherapeutic drugs.
Biochem/physiol Actions: STF-118804 is a highly specific and potent NAMPT (nicotinamide phosphoribosyl transferase) inhibitor that reduces the viability of most B-ALL cell lines. STF 118804 induces leukemia cell apoptosis including leukemia initiating (stem) cells. STF 118804 improves survival in an orthotopic xenotransplant model of high-risk acute lymphoblastic leukemia.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 51111800

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