CINK4
SIGMA/SML1352 - ≥95% (HPLC)
Synonym: trans-
CAS Number: 359886-84-3
Empirical Formula (Hill Notation): C27H32N6O
Molecular Weight: 456.58
Linear Formula: C27H32N6O
Product Type: Chemical
assay | ≥95% (HPLC) |
color | white to light brown |
form | powder |
InChI | 1S/C27H32N6O/c1-2-28-25-1 |
InChI key | YVXCDLCJCIDFHE-AFARHQOCSA |
Quality Level | 100 |
SMILES string | O[C@@H]1CC[C@@H](NC2=CC(N |
solubility | DMSO: 25 mg/mL, clear |
storage temp. | 2-8°C |
Biochem/physiol Actions: | CINK4 is a specific inhbitor of CDK4/cyclin D1 complexes (IC50 = 1.5 mM). CINK4 has greater than 50 fold selectivity over CDK1 or CDK2. CINK4 dose-dependently inhibits phosphorylation of retinoblastoma (Rb) and induces G0-G1 cell cycle arrest and apoptosis in cancer cell lines. |
Packaging: | 5, 25 mg in glass bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥95% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |