Synonym: (S)2-CyclopentylN((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro1Hpyrrido[3,4b]indole-4-carboxamide hydrochloride
CAS Number: 1638646-27-1 (free base)
Empirical Formula (Hill Notation): C26H34N4O2 · HCl
Molecular Weight: 471.03
MDL Number: MFCD28987471
Linear Formula: C26H34N4O2 · HCl
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
white to beige |
| form |
powder |
| InChI |
1S/C26H34N4O2.ClH/c1-17(2)29-14-8-11-19(29)15-27-25(31)21-16-30(18-9-4-5-10-18)26(32)24-23(21)20-12-6-7-13-22(20)28(24)3;/h6-7,12-13,16-19H,4-5,8-11,14-15H2,1-3H3,(H,27,31);1H/t19-;/m0./s1 |
| InChI key |
OCMGNMGYQPPMFF-FYZYNONXSA-N |
| Quality Level |
100  |
| SMILES string |
CN1C2=C(C(C(NC[C@@H]3CCCN3C(C)C)=O)=CN(C4CCCC4)C2=O)C5=CC=CC=C51.Cl |
| solubility |
H2O: 20 mg/mL, clear |
| storage condition |
desiccated |
| storage temp. |
2-8°C |
| Biochem/physiol Actions: |
VU0453379 is a highly selective CNS penetrant positive allosteric modulator of Glucagon-like peptide-1 (GLP-1) with GLP-1 EC50 = 1.3 μ,M, 59.2% GLP-1 max. VU0453379 potentiated low-dose exenatide to augment insulin secretion in primary mouse pancreatic islets. In a model of Parkinson’s disease it showed a significant reversal of haloperidol-induced catalepsy at 30 mg/kg. |
| Biochem/physiol Actions: |
VU0453379 is a highly selective CNS penetrant positive allosteric modulator of Glucagon-like peptide-1 (GLP-1). |
| Packaging: |
5, 25 mg in glass bottle |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
2-8°C |
| UNSPSC |
51111800 |
