VU0453379 hydrochloride
SIGMA/SML1357 - ≥98% (HPLC)
Synonym: (S)
CAS Number: 1638646-27-1 (free base)
Empirical Formula (Hill Notation): C26H34N4O2 · HCl
Molecular Weight: 471.03
MDL Number: MFCD28987471
Linear Formula: C26H34N4O2 · HCl
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C26H34N4O2.ClH/c1-17(2 |
InChI key | OCMGNMGYQPPMFF-FYZYNONXSA |
Quality Level | 100 |
SMILES string | CN1C2=C(C(C(NC[C@@H]3CCCN |
solubility | H2O: 20 mg/mL, clear |
storage condition | desiccated |
storage temp. | 2-8°C |
Biochem/physiol Actions: | VU0453379 is a highly selective CNS penetrant positive allosteric modulator of Glucagon-like peptide-1 (GLP-1) with GLP-1 EC50 = 1.3 μ,M, 59.2% GLP-1 max. VU0453379 potentiated low-dose exenatide to augment insulin secretion in primary mouse pancreatic islets. In a model of Parkinson’s disease it showed a significant reversal of haloperidol-induced catalepsy at 30 mg/kg. |
Packaging: | 5, 25 mg in glass bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 51111800 |