L755507
SIGMA/SML1362 - ≥98% (HPLC)
Synonym: 4-
CAS Number: 159182-43-1
Empirical Formula (Hill Notation): C30H40N4O6S
Molecular Weight: 584.73
Linear Formula: C30H40N4O6S
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C30H40N4O6S/c1-2-3-4-5 |
InChI key | NYYJKMXNVNFOFQ-MHZLTWQESA |
Quality Level | 100 |
SMILES string | OC1=CC=C(OC[C@@H](O)CNCCC |
solubility | DMSO: 20 mg/mL, clear |
storage temp. | 2-8°C |
Application: | L755507 has been shown to enhance CRISPR genome editing efficiency. To see other small molecule CRISPR enhancers, visit sigma.com/CRISPR-enhancer |
Biochem/physiol Actions: | L755507 is a potent β3-adrenergic receptor partial agonist with an EC50 value of 0.43 nM for β3 receptors with over 440-fold selectivity for β3 compared to β1 and β2-adrenergic receptor binding. L755507 has been shown to enhance CRISPR-mediated homology-directed repair (HDR) efficiency in human induced pluripotent stem cells (iPSCs), increasing the efficiency of GFP insertion by 3-fold compared to control cells. |
Biochem/physiol Actions: | L755507 is a potent β3-adrenergic receptor partial agonist. |
Biochem/physiol Actions: | L755507 is found to stimulate the breakdown of lipids in human adipose tissues. L755507 also promotes urinary bladder relaxation. |
General description: | L755507 is a derivative of 4-acylaminobenzenesulfona |
Packaging: | 5, 25 mg in glass bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |