CLP257
SIGMA/SML1368 - ≥98% (HPLC)
Synonym: (5Z)
CAS Number: 1181081-71-9
Empirical Formula (Hill Notation): C14H14FN3O2S
Molecular Weight: 307.34
MDL Number: MFCD28166488
Linear Formula: C14H14FN3O2S
Product Type: Chemical
assay | ≥98% (HPLC) |
color | , white to yellow to light brown |
form | powder |
InChI | 1S/C14H14FN3O2S/c15-10-4- |
InChI key | SKCADXVKQRCWTR-GHXNOFRVSA |
Quality Level | 100 |
SMILES string | O=C1/C(SC(N2CCCCN2)=N1)=C |
solubility | DMSO: 20 mg/mL, clear |
storage temp. | 2-8°C |
Application: | CLP257 has been used as a K+- Cl- cotransporter 2 (KCC2) enhancer in human neuron culture. |
Biochem/physiol Actions: | CLP257 is a selective K+-Cl− cotransporter KCC2 activator that restored impaired Cl− transport in neurons with reduced KCC2 activity. Apparently, CLP257 modulates plasmalemmal KCC2 protein turnover post-translationally. |
Biochem/physiol Actions: | In streptozotocin treated rats, by activating a K+- Cl- cotransporter 2 (KCC2) in the arginine-vasopressin neuron, CLP257 mediates γ-aminobutyric acid (GABA)ergic excitation. It is however inactive with KCC1, KCC3 and KCC4. |
Packaging: | 5, 25 mg in glass bottle |
Symbol | GHS07 |
Signal word | Warning |
Hazard statements | H302 |
Precautionary statements | P301 + P312 + P330 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |