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CLP257

SIGMA/SML1368 - ≥98% (HPLC)

Synonym: (5Z)-5-[(4-Fluoro-2-hydroxyphenyl)methylene]-2-(tetrahydro-1-(2H)-pyridazinyl)-4(5H)-thiazolone

CAS Number: 1181081-71-9
Empirical Formula (Hill Notation): C14H14FN3O2S
Molecular Weight: 307.34
MDL Number: MFCD28166488
Linear Formula: C14H14FN3O2S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1368-5MG 5 mg
 $146.00
1/EA		 Add To Favorites
45-SML1368-25MG 25 mg
 $574.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color , white to yellow to light brown
form powder
InChI 1S/C14H14FN3O2S/c15-10-4-3-9(11(19)8-10)7-12-13(20)17-14(21-12)18-6-2-1-5-16-18/h3-4,7-8,16,19H,1-2,5-6H2/b12-7-
InChI key SKCADXVKQRCWTR-GHXNOFRVSA-N
Quality Level 100 
SMILES string O=C1/C(SC(N2CCCCN2)=N1)=C/C3=CC=C(F)C=C3O
solubility DMSO: 20 mg/mL, clear
storage temp. 2-8°C
Application: CLP257 has been used as a K+- Cl- cotransporter 2 (KCC2) enhancer in human neuron culture.
Biochem/physiol Actions: CLP257 is a selective K+-Cl− cotransporter KCC2 activator that restored impaired Cl− transport in neurons with reduced KCC2 activity. Apparently, CLP257 modulates plasmalemmal KCC2 protein turnover post-translationally.
Biochem/physiol Actions: CLP257 is a selective K+-Cl− cotransporter KCC2 activator.
Biochem/physiol Actions: In streptozotocin treated rats, by activating a K+- Cl- cotransporter 2 (KCC2) in the arginine-vasopressin neuron, CLP257 mediates γ-aminobutyric acid (GABA)ergic excitation. It is however inactive with KCC1, KCC3 and KCC4.
Packaging: 5, 25 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Precautionary statements P301 + P312 + P330
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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