Prucalopride
SIGMA/SML1371 - ≥98% (HPLC)
Synonym: 4-
CAS Number: 179474-81-8
Empirical Formula (Hill Notation): C18H26ClN3O3
Molecular Weight: 367.87
Linear Formula: C18H26ClN3O3
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C18H26ClN3O3/c1-24-9-2 |
InChI key | ZPMNHBXQOOVQJL-UHFFFAOYSA |
Quality Level | 100 |
SMILES string | COCCCN1CCC(NC(C2=CC(Cl)=C |
solubility | DMSO: 20 mg/mL, clear |
storage temp. | 2-8°C |
Biochem/physiol Actions: | In healthy male individuals, prucalopride decreases the display of esophageal acid and promotes gastric emptying. It is effective, safe and shows good tolerance for the treatment of men with chronic constipation. |
Biochem/physiol Actions: | Prucalopride is a selective 5-HT4 serotonin receptor agonist with enterokinetic activity. 5-HT4 receptors are GPCRs that are expressed in the CNS and peripheral tissues. The receptor has a role in GI motility disorders such as irritable bowel syndrome and idiopathic constipation. Agonists are prokinetic and of potential use for disoroders of reduced motility. Prucalopride is a selective 5-HT4 serotonin receptor agonist with enterokinetic activities. Prucalopride has pK(i) values of 8.60 and 8.10 for the human 5-HT(4a) and 5-HT(4b) receptor, respectively, and at least 290-fold selectivity for 5-HT4 over other serotonin and dopamine receptors. |
Packaging: | 10, 50 mg in glass bottle |
Symbol | GHS07,GHS09 |
Signal word | Warning |
Hazard statements | H315 - H319 - H335 - H400 |
Precautionary statements | P273 - P302 + P352 - P305 + P351 + P338 |
RIDADR | UN 3077 9 / PGIII |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |