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Prucalopride

SIGMA/SML1371 - ≥98% (HPLC)

Synonym: 4-Amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide

CAS Number: 179474-81-8
Empirical Formula (Hill Notation): C18H26ClN3O3
Molecular Weight: 367.87
Linear Formula: C18H26ClN3O3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1371-10MG 10 mg
 $79.70
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45-SML1371-50MG 50 mg
 $323.00
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assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C18H26ClN3O3/c1-24-9-2-6-22-7-3-12(4-8-22)21-18(23)14-11-15(19)16(20)13-5-10-25-17(13)14/h11-12H,2-10,20H2,1H3,(H,21,23)
InChI key ZPMNHBXQOOVQJL-UHFFFAOYSA-N
Quality Level 100 
SMILES string COCCCN1CCC(NC(C2=CC(Cl)=C(N)C3=C2OCC3)=O)CC1
solubility DMSO: 20 mg/mL, clear
storage temp. 2-8°C
Biochem/physiol Actions: In healthy male individuals, prucalopride decreases the display of esophageal acid and promotes gastric emptying. It is effective, safe and shows good tolerance for the treatment of men with chronic constipation.
Biochem/physiol Actions: Prucalopride is a selective 5-HT4 serotonin receptor agonist with enterokinetic activity.
Biochem/physiol Actions: Prucalopride is a selective 5-HT4 serotonin receptor agonist with enterokinetic activity. 5-HT4 receptors are GPCRs that are expressed in the CNS and peripheral tissues. The receptor has a role in GI motility disorders such as irritable bowel syndrome and idiopathic constipation. Agonists are prokinetic and of potential use for disoroders of reduced motility. Prucalopride is a selective 5-HT4 serotonin receptor agonist with enterokinetic activities. Prucalopride has pK(i) values of 8.60 and 8.10 for the human 5-HT(4a) and 5-HT(4b) receptor, respectively, and at least 290-fold selectivity for 5-HT4 over other serotonin and dopamine receptors.
Packaging: 10, 50 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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