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Nifetepimine

SIGMA/SML1372 - ≥95% (HPLC)

Synonym: 1,2,3,4-Tetrahydro-6-methyl-4-(3-nitrophenyl)-2-oxo-5-pyrimidinecarboxylic acid ethyl ester; 5-Ethoxycarbonyl-6-methyl-4-(3-nitrophenyl)-3,4-dihydropyrimidin-2(1H)-one; 6-Methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester; Ethyl-4-(3-nitrophenyl)-6-methyl-2-oxo-1,2,3,4 tetrahydropyrimidine-5 carboxylate

CAS Number: 110448-29-8
Empirical Formula (Hill Notation): C14H15N3O5
Molecular Weight: 305.29
MDL Number: MFCD00128568
Linear Formula: C14H15N3O5
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1372-25MG 25 mg
 $292.00
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assay ≥95% (HPLC)
color white to beige
form powder
InChI 1S/C14H15N3O5/c1-3-22-13(18)11-8(2)15-14(19)16-12(11)9-5-4-6-10(7-9)17(20)21/h4-7,12H,3H2,1-2H3,(H2,15,16,19)
InChI key PPBNQKLDXXHPMH-UHFFFAOYSA-N
Quality Level 100 
SMILES string O=C(OCC)C1=C(C)NC(NC1C2=CC([N+]([O-])=O)=CC=C2)=O
solubility DMSO: 10 mg/mL, clear
storage temp. 2-8°C
Biochem/physiol Actions: Nifetepimine is a dihydropyrimidone calcium channel blocker that down-modulates SERCA3 (sarco/endoplasmic reticulum Ca2+ -ATPase 3) pump, and protects of the CD4+ T cells from tumor-induced apoptosis. Nifetepimine induces apoptotic cell death in triple negative breast cancer (TNBC) cells by stimulation of cross-talk between ER stress and the MEK/ERK pathway.
Biochem/physiol Actions: Nifetepimine is a dihydropyrimidone calcium channel blocker.
Packaging: 5, 25 mg in glass bottle
Purity ≥95% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352202

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