Galeterone

SIGMA/SML1375 - ≥98% (HPLC)

Synonym: 3β-Hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene; TOK-001; VN-124-1; VN/124-1

CAS Number: 851983-85-2
Empirical Formula (Hill Notation): C₂₆H₃₂N₂O
Molecular Weight: 388.55
MDL Number: MFCD16660907
Linear Formula: C₂₆H₃₂N₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML1375-5MG	5 mg	$91.90 1/EA	Add To Favorites
45-SML1375-25MG	25 mg	$370.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C26H32N2O/c1-25-13-11-18(29)15-17(25)7-8-19-20-9-10-24(26(20,2)14-12-21(19)25)28-16-27-22-5-3-4-6-23(22)28/h3-7,10,16,18-21,29H,8-9,11-15H2,1-2H3/t18-,19-,20-,21-,25-,26-/m0/s1
InChI key	PAFKTGFSEFKSQG-PAASFTFBSA-N
Quality Level	100
SMILES string	C[C@]12C(C[C@@H](O)CC2)=CC[C@]3([H])[C@]1([H])CC[C@@]4(C)[C@@]3([H])CC=C4N5C=NC6=C5C=CC=C6
solubility	DMSO: 20 mg/mL, clear
storage temp.	−20°C

Biochem/physiol Actions:

Galeterone is an inhibitor of CYP17A1 (CYP450c17), an enzyme that catalyzes two key serial reactions (17-α hydroxylase and 17,20 lyase) in androgen and estrogen biosynthesis resulting in the formation of DHEA and androstenedione, which may ultimately be metabolized into testosterone. CYP17 is the key enzyme for androgen biosynthesis in both the testes and adrenals, so its inhibition should stop the production of androgens in both places. Galeterone, moreover, is a potent blocker of the androgen receptor and causes down-regulation of androgen receptor (AR) protein expression in vitro and in vivo.

Packaging:

5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	51111800

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