OG-L002 hydrochloride
SIGMA/SML1383 - ≥98% (HPLC)
Synonym: 4′-((1R,2S)-2-Aminocyclopropyl)-[1,1′-biphenyl]-3-ol hydrochloride
CAS Number: 1357299-45-6
Empirical Formula (Hill Notation): C15H15NO · HCl
Molecular Weight: 261.75
Linear Formula: C15H15NO · HCl
Product Type: Chemical
assay | ≥98% (HPLC) |
color | , light yellow to dark orange |
form | powder |
InChI | 1S/C15H15NO.ClH/c16-15-9- |
InChI key | LPVCAMIPTMRRLZ-LIOBNPLQSA |
Quality Level | 100 |
SMILES string | N[C@@H]1[C@@H](C(C=C2)=CC |
solubility | DMSO: 20 mg/mL, clear |
storage condition | desiccated |
storage temp. | 2-8°C |
Biochem/physiol Actions: | OG-L002 is a recently developed inhibitor with IC50 of 20 nM at LSD1 and much lower activity at MAO-A and MAO-B (1.38 and 0.72 μM, respectively). OG-L002 exhibits potent anti-viral activity in vitro and in mouse models of HSV infection. Lysine specific demethylase 1 (LSD1) is a histone demethylase that removes methyl groups from lysine 4 or 9 of H3 histone tails. Inhibition of LSD1 leds to suppression of herpes simplex and herpes zoster viral infections and viral reactivation from latency. MAO inhibitors (pargyline, tranylcypromine) are known to inhibit LSD1, but with low potency and selectivity. OG-L002 is a more selective and potent tool for LSD1 inhibition. |
Packaging: | 5, 25 mg in glass bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |