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Lomitapide

SIGMA/SML1385 - ≥98% (HPLC)

Synonym: AEGR-733; BMS-201038; N-(2,2,2-Trifluoroethyl)-9-[4-[4-[[[4′-(trifluoromethyl)[1,1′-biphenyl]2-yl]carbonyl]amino]-1-piperidinyl]butyl]9H-fluoren-9-carboxamde

CAS Number: 182431-12-5
Empirical Formula (Hill Notation): C39H37F6N3O2
Molecular Weight: 693.72
MDL Number: MFCD16620494
Linear Formula: C39H37F6N3O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1385-5MG 5 mg
 $200.00
1/EA		 Add To Favorites
45-SML1385-25MG 25 mg
 $763.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SML1385-25MG.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C39H37F6N3O2/c40-38(41,42)25-46-36(50)37(33-13-5-3-10-30(33)31-11-4-6-14-34(31)37)21-7-8-22-48-23-19-28(20-24-48)47-35(49)32-12-2-1-9-29(32)26-15-17-27(18-16-26)39(43,44)45/h1-6,9-18,28H,7-8,19-25H2,(H,46,50)(H,47,49)
InChI key MBBCVAKAJPKAKM-UHFFFAOYSA-N
Quality Level 100 
SMILES string O=C(NCC(F)(F)F)C1(C(C=CC=C2)=C2C3=C1C=CC=C3)CCCCN(CC4)CCC4NC(C5=C(C6=CC=C(C(F)(F)F)C=C6)C=CC=C5)=O
solubility DMSO: 20 mg/mL, clear
storage temp. 2-8°C
Application: Lomitapide has been used as a microsomal triglyceride transfer protein (MTP) inhibitor to study its effects on very-low-density lipoproteins (VLDL) export in mouse hepatocytes.
Biochem/physiol Actions: Lomitapide can lower the secretion of very-low-density lipoproteins (VLDL) and chylomicrons.
Biochem/physiol Actions: Lomitapide is an inhibitor of microsomal triglyceride transfer protein (MTP).
Biochem/physiol Actions: Lomitapide is an inhibitor of microsomal triglyceride transfer protein (MTP). Lomitapide has been shown to be highly effective in reducing LDL-cholesterol and triglycerides, and has been aproved for treatment of homozygous familial hypercholesterolemia.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 51111800

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