Fexaramine
SIGMA/SML1390 - ≥98% (HPLC)
Synonym: 3-
CAS Number: 574013-66-4
Empirical Formula (Hill Notation): C32H36N2O3
Molecular Weight: 496.64
MDL Number: MFCD09971007
Linear Formula: C32H36N2O3
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C32H36N2O3/c1-33(2)29- |
| InChI key | VLQTUNDJHLEFEQ-KGENOOAVSA |
| Quality Level | 100  |
| SMILES string | CN(C)C(C=C1)=CC=C1C2=CC=C |
| solubility | DMSO: 10 mg/mL, clear |
| storage condition | desiccated |
| storage temp. | 2-8°C |
| Application: | Fexaramine has been used to study its action on RANKL (receptor activator of nuclear factor-κB ligand)-induced osteoclastogenesis in mouse model. |
| Biochem/physiol Actions: | Fexaramine is a potent and selective agonist of the bile acid sensor farnesoid X receptor (FXR) in the gut with an EC50 of 25 nM and no activity found for other nuclear receptors. Fexaramine induces enteric fibroblast growth factor 15 (FGF15), causing alterations in bile acid composition without activating FXR target genes in the liver. In mouse studies, fexaramine enhanced thermogenesis and browning of white adipose tissue while reducing diet-induced weight gain, body-wide inflammation and hepatic glucose production. Fexaramine also improved insulin responsiveness. |
| Biochem/physiol Actions: | Fexaramine might regulate lipid and glucose metabolism and can serve as a therapeutic target in the treatment of fatty liver disease, type 2 diabetes and obesity. Fexaramine might mediate cholesterol homeostasis and promotes osteoblast differentiation and suppresses differentiation of osteoclast. |
| General description: | Fexaramine belongs to the nuclear hormone receptor family. |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 - H413 |
| Precautionary statements | P273 - P301 + P312 + P330 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |