Heclin

SIGMA/SML1396 - ≥98% (HPLC)

Synonym: N-(4-Acetylphenyl)-3-(5-ethyl-2-furanyl)-2-propenamide

CAS Number: 890605-54-6
Empirical Formula (Hill Notation): C₁₇H₁₇NO₃
Molecular Weight: 283.32
Linear Formula: C₁₇H₁₇NO₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SML1396-5MG	5 mg	$114.00 1/EA		Add To Favorites
45-SML1396-25MG	25 mg	$444.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C17H17NO3/c1-3-15-8-9-16(21-15)10-11-17(20)18-14-6-4-13(5-7-14)12(2)19/h4-11H,3H2,1-2H3,(H,18,20)/b11-10+
InChI key	SPTWXRJNCFIDRQ-ZHACJKMWSA-N
Quality Level	100
SMILES string	CC(C1=CC=C(NC(/C=C/C2=CC=C(CC)O2)=O)C=C1)=O
solubility	DMSO: 20 mg/mL, clear
storage temp.	2-8°C

Application:	Heclin has been used as a HECT-type ubiquitin E3 ligase inhibitor in human embryonic kidney (HEK293) cells. It has also been used to test its effect on dandelion-induced chloride channel protein (ClC-Ka) inhibition in HEK293 cells and fibroblast-like COS-7 cell line.
Biochem/physiol Actions:	Heclin is a selective reversible inihbitor of HECT E3 ubiquitin ligases. Heclin inhibited Nedd4, Smurf2 and WWP1 with IC₅₀ values of 6.3 μM, 6.8 μM and 6.9 μM, respectively, and inhibited autoubiquitination of the Smurf2 HECT domain in vivo with an IC₅₀ value of 9 μM. Heclin had no effect on the auto-ubiquitination of the RING domain ligase Mdm2.
Biochem/physiol Actions:	Heclin is not effective in inhibiting E1 or E2 proteins.
Biochem/physiol Actions:	HECT E3 ubiquitin ligase inhibitor
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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